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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Etv6tm2Sho
targeted mutation 2, Stuart H Orkin
MGI:3056142
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Etv6tm2Sho/Etv6tm2Sho involves: 129S1/Sv MGI:3056262
cn2
 		Etv6tm2Sho/Etv6tm2Sho
Tg(Gata1-cre)1Sho/? 		involves: 129S1/Sv MGI:3056263
cn3
 		Etv6tm2Sho/Etv6tm2Sho
Tg(Mx1-cre)1Cgn/? 		involves: 129S1/Sv * C57BL/6 * CBA MGI:3056264


Genotype
MGI:3056262
hm1
Allelic
Composition		 Etv6tm2Sho/Etv6tm2Sho
Genetic
Background		 involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Etv6tm2Sho mutation (0 available); any Etv6 mutation (144 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype




Genotype
MGI:3056263
cn2
Allelic
Composition		 Etv6tm2Sho/Etv6tm2Sho
Tg(Gata1-cre)1Sho/?
Genetic
Background		 involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Etv6tm2Sho mutation (0 available); any Etv6 mutation (144 available)
Tg(Gata1-cre)1Sho mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal megakaryocyte differentiation ( J:93052 )
• megakaryocyte colony forming cells increased 5 fold
thrombocytopenia ( J:93052 )
• platelet count is reduced 50%

cellular
abnormal megakaryocyte differentiation ( J:93052 )
• megakaryocyte colony forming cells increased 5 fold




Genotype
MGI:3056264
cn3
Allelic
Composition		 Etv6tm2Sho/Etv6tm2Sho
Tg(Mx1-cre)1Cgn/?
Genetic
Background		 involves: 129S1/Sv * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Etv6tm2Sho mutation (0 available); any Etv6 mutation (144 available)
Tg(Mx1-cre)1Cgn mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased neutrophil cell number ( J:93052 )
• moderately reduced neutrophile counts
thrombocytopenia ( J:93052 )
• dramatically reduced platelet counts
• platelet recovery after about 4 weeks

immune system
decreased neutrophil cell number ( J:93052 )
• moderately reduced neutrophile counts




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory