Phenotypes associated with this allele

• Allele Symbol: Etv6^tm2.1Sho
• Allele Name: targeted mutation 2.1, Stuart H Orkin
• Allele ID: MGI:3056143
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Etv6^tm2.1Sho/Etv6^tm2.1Sho	involves: 129S1/Sv	MGI:3056261

Genotype
MGI:3056261

hm1

• Allelic Composition: Etv6^tm2.1Sho/Etv6^tm2.1Sho
• Genetic Background: involves: 129S1/Sv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, incomplete penetrance ( J:93052 )

• about 95% of embryos died by E11

prenatal lethality, complete penetrance ( J:93052 )

• embryos surviving past E11 were superficially normal at E18.5 but still not born alive

embryo

absent vitelline blood vessels ( J:93052 )

• failure of yolk sac angiogenesis in embryos dying before E11

hematopoietic system

abnormal erythropoiesis ( J:93052 )

• mice surviving past E11 with normal fetal liver hematopoiesis

• markedly reduced bone marrow hematopoiesis

cardiovascular system

absent vitelline blood vessels ( J:93052 )

• failure of yolk sac angiogenesis in embryos dying before E11