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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Myh6-NFATC4)#Eno
transgene insertion, Eric N Olson
MGI:3056187
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Nfatc3tm1Glm/Nfatc3tm1Glm
Nfatc4tm1Jmk/Nfatc4tm1Jmk
Tg(Myh6-NFATC4)#Eno/? 		involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6 * FVB MGI:3836583
tg2
 		Tg(Myh6-NFATC4)#Eno/0 involves: FVB MGI:3056190


Genotype
MGI:3836583
cx1
Allelic
Composition		 Nfatc3tm1Glm/Nfatc3tm1Glm
Nfatc4tm1Jmk/Nfatc4tm1Jmk
Tg(Myh6-NFATC4)#Eno/?
Genetic
Background		 involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfatc3tm1Glm mutation (1 available); any Nfatc3 mutation (71 available)
Nfatc4tm1Jmk mutation (1 available); any Nfatc4 mutation (38 available)
Tg(Myh6-NFATC4)#Eno mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:84138 )
• viability extended to around E12
• no live embryos at E12.5 or later

cardiovascular system
cardiovascular system phenotype ( J:84138 )
N
• normal heart phenotype at E11.5
• heart mitochondrial respiration normal at E10.5
• 70% of mitochondria are normal in heart muscle at E10.5




Genotype
MGI:3056190
tg2
Allelic
Composition		 Tg(Myh6-NFATC4)#Eno/0
Genetic
Background		 involves: FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
myocardial fiber disarray ( J:93176 )
• myofiber disarray is seen
cardiac hypertrophy ( J:93176 )
• concentric hypertrophy is seen in both ventricles

growth/size/body
cardiac hypertrophy ( J:93176 )
• concentric hypertrophy is seen in both ventricles

muscle
myocardial fiber disarray ( J:93176 )
• myofiber disarray is seen




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory