Phenotypes associated with this allele

• Allele Symbol: Nodal^tm5Rob
• Allele Name: targeted mutation 5, Elizabeth J Robertson
• Allele ID: MGI:3056345
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Meox2^tm1(cre)Sor/Meox2^+ Nodal^tm1Rob/Nodal^tm5Rob	involves: 129S/SvEv * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6	MGI:3056368
cn2	Nodal^tm1Rob/Nodal^tm5Rob Edil3^Tg(Sox2-cre)1Amc/Edil3^+	involves: 129S/SvEv * C57BL/6	MGI:3056367

Genotype
MGI:3056368

cn1

• Allelic Composition: Meox2^tm1(cre)Sor/Meox2⁺; Nodal^tm1Rob/Nodal^tm5Rob
• Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

abnormal developmental patterning ( J:93140 )

• development was variable

abnormal proximal-distal axis patterning ( J:93140 )

• fail to rotate their proximal distal axis

rostral body truncation ( J:93140 )

• variable amounts of anterior truncation at E6.5

• in severe cases an elongate morphology at E6.5

• profound anterior truncations by E8.5

abnormal visceral yolk sac morphology ( J:93140 )

• embryos occasionally protrude outside the yolk sac at E6.5

Genotype
MGI:3056367

cn2

• Allelic Composition: Nodal^tm1Rob/Nodal^tm5Rob; Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺
• Genetic Background: involves: 129S/SvEv * C57BL/6

embryo

abnormal developmental patterning ( J:93140 )

abnormal germ layer development ( J:93140 )

absent mesoderm ( J:93140 )

• lacked mesoderm at gastrulation

abnormal distal visceral endoderm morphology ( J:93140 )

• thickened distal visceral endoderm