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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mcph1Tg(HLA-A2.1)1Enge
transgene insertion 1, Victor H Engelhard
MGI:3056375
Summary 7 genotypes


Genotype
MGI:3723606
hm1
Allelic
Composition		 Mcph1Tg(HLA-A2.1)1Enge/Mcph1Tg(HLA-A2.1)1Enge
Genetic
Background		 NOD.B6-Mcph1Tg(HLA-A2.1)1Enge
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcph1Tg(HLA-A2.1)1Enge mutation (7 available); any Mcph1 mutation (58 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:109851 )
N
• proportions of splenic B cells, CD4, and CD8 T cells are comparable to controls; no differences in CD4+CD25+ T cell numbers or expression levels of endogenous murine MHC class I molecules are found
increased susceptibility to autoimmune diabetes ( J:109851 )
• homozygous and hemizygous mice develop type I diabetes at a significantly accelerated rate compared to NOD controls




Genotype
MGI:3623498
ht2
Allelic
Composition		 Mcph1Tg(HLA-A2.1)1Enge/Mcph1+
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcph1Tg(HLA-A2.1)1Enge mutation (7 available); any Mcph1 mutation (58 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal immune tolerance ( J:52612 )
• transgenic animals are more tolerant to HLA-A2.1-expressing murine cells than control mice primed once with influenza virus; numbers of cytotoxic T lymphocyte precursors are 100-fold higher in primed C57BL/6 controls




Genotype
MGI:5703838
ht3
Allelic
Composition		 Mcph1Tg(HLA-A2.1)1Enge/Mcph1+
Genetic
Background		 NOD.B6-Mcph1Tg(HLA-A2.1)1Enge
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcph1Tg(HLA-A2.1)1Enge mutation (7 available); any Mcph1 mutation (58 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased susceptibility to autoimmune diabetes ( J:109851 )
• homozygous and hemizygous mice develop type I diabetes at a significantly accelerated rate compared to NOD controls




Genotype
MGI:5707036
cx4
Allelic
Composition		 B2mtm1Unc/B2mtm1Unc
Emv30b/Emv30b
Prkdcscid/Prkdcscid
Tg(B2M)55Hpl/?
Mcph1Tg(HLA-A2.1)1Enge/?
Genetic
Background		 NOD.Cg-B2mtm1Unc Mcph1Tg(HLA-A2.1)1Enge Emv30b Prkdcscid Tg(B2M)55Hpl/Dvs
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
B2mtm1Unc mutation (38 available); any B2m mutation (122 available)
Emv30b mutation (3 available); any Emv30 mutation (3 available)
Mcph1Tg(HLA-A2.1)1Enge mutation (7 available); any Mcph1 mutation (58 available)
Prkdcscid mutation (178 available); any Prkdc mutation (417 available)
Tg(B2M)55Hpl mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to autoimmune diabetes ( J:109851 )
• these mice do not develop diabetes and they provide a host in cell transfer studies for assessing HLA-A2.1 selected T cell pathogenicity




Genotype
MGI:3723607
cx5
Allelic
Composition		 B2mtm1Unc/B2mtm1Unc
Tg(B2M)55Hpl/Tg(B2M)55Hpl
Mcph1Tg(HLA-A2.1)1Enge/Mcph1Tg(HLA-A2.1)1Enge
Genetic
Background		 NOD.Cg-B2mtm1Unc Mcph1Tg(HLA-A2.1)1Enge Tg(B2M)55Hpl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
B2mtm1Unc mutation (38 available); any B2m mutation (122 available)
Mcph1Tg(HLA-A2.1)1Enge mutation (7 available); any Mcph1 mutation (58 available)
Tg(B2M)55Hpl mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased susceptibility to autoimmune diabetes ( J:109851 )
• mice develop diabetes at a rate similar to NOD control females, whereas transgenic animals not expressing Tg(HLA-A2.1)1Enge are normally diabetes-resistant




Genotype
MGI:3845377
cx6
Allelic
Composition		 Prkdcscid/Prkdcscid
Mcph1Tg(HLA-A2.1)1Enge/Mcph1+
Genetic
Background		 NOD.Cg-Mcph1Tg(HLA-A2.1)1Enge Prkdcscid/Dvs
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcph1Tg(HLA-A2.1)1Enge mutation (7 available); any Mcph1 mutation (58 available)
Prkdcscid mutation (178 available); any Prkdc mutation (417 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal splenocyte morphology ( J:91764 )
• more than 95% of splenocytes express high levels of human HLA-A2.1 protein on their cell surface

immune system
abnormal splenocyte morphology ( J:91764 )
• more than 95% of splenocytes express high levels of human HLA-A2.1 protein on their cell surface




Genotype
MGI:3844698
cx7
Allelic
Composition		 Prkdcscid/Prkdcscid
Tg(B2M)55Hpl/0
Mcph1Tg(HLA-A2.1)1Enge/Mcph1+
Genetic
Background		 NOD.Cg-Mcph1Tg(HLA-A2.1)1Enge Prkdcscid Tg(B2M)55Hpl/Sz
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcph1Tg(HLA-A2.1)1Enge mutation (7 available); any Mcph1 mutation (58 available)
Prkdcscid mutation (178 available); any Prkdc mutation (417 available)
Tg(B2M)55Hpl mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased circulating glucose level ( J:91764 )
• when islet and HLA-A2 negative human peripheral blood mononuclear cells are transplanted into streptozotocin-treated Rag1tm1Mom Prf1tm1Sdz homozygotes serum glucose remains high
• however, when islet and HLA-A2 positive human peripheral blood mononuclear cells are transplanted into streptozotocin-treated Rag1tm1Mom Prf1tm1Sdz homozygotes euglycemia is achieved

immune system
abnormal response to transplant ( J:91764 )
• when islet and HLA-A2 negative human peripheral blood mononuclear cells are transplanted into streptozotocin-treated Rag1tm1Mom Prf1tm1Sdz homozygotes engrafted islet cells are destroyed




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11/12/2024
MGI 6.24 		The Jackson Laboratory