Phenotypes associated with this allele

• Allele Symbol: Dll4^tm1Grid
• Allele Name: targeted mutation 1, Tom Gridley
• Allele ID: MGI:3056460
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Dll4^tm1Grid/Dll4^+	either: (involves: 129X1/SvJ * Black Swiss) or (involves: 129X1/SvJ * C57BL/6J)	MGI:3056463

Genotype
MGI:3056463

ht1

• Allelic Composition: Dll4^tm1Grid/Dll4⁺
• Genetic Background: either: (involves: 129X1/SvJ * Black Swiss) or (involves: 129X1/SvJ * C57BL/6J)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:93125 )

• only a single heterozygote was produced and no heterozygous pups were produced from mating this individual to wild-type Black Swiss females

cardiovascular system

abnormal dorsal aorta morphology ( J:93125 )

• some embryos also have more caudal fusions of the dorsal aorta to the common cardinal vein

abnormal capillary morphology ( J:93125 )

• the capillary system is less extensive and more primitive compared to wild-type

abnormal vascular regression ( J:93125 )

• no vascular remodeling is seen at E9.5

abnormal anterior cardinal vein morphology ( J:93125 )

• the distal outflow tract is connected to the anterior cardinal vein by an anastamoses

abnormal common cardinal vein morphology ( J:93125 )

• some embryos also have more caudal fusions of the dorsal aorta to the common cardinal vein

arteriovenous malformation ( J:93125 )

• the distal outflow tract is connected to the anterior cardinal vein by an anastamoses

• some embryos also have more caudal fusions of the dorsal aorta to the common cardinal vein

blood vessel atresia ( J:93125 )

• some vessels are reduced in diameter or atretic

pericardial effusion ( J:93125 )

• pericardial effusion is seen at E9.5 and E10.5

embryo

embryonic growth retardation ( J:93125 )

• embryonic growth retardation is seen at E9.5 and E10.5

abnormal vitelline vascular remodeling ( J:93125 )

• a mottled avascular yolk sac is seen at E9.5 and E10.5

• the yolk sac primary plexus is not remodeled

growth/size/body

embryonic growth retardation ( J:93125 )

• embryonic growth retardation is seen at E9.5 and E10.5

homeostasis/metabolism

pericardial effusion ( J:93125 )

• pericardial effusion is seen at E9.5 and E10.5

cellular

abnormal vascular regression ( J:93125 )

• no vascular remodeling is seen at E9.5