Phenotypes associated with this allele

• Allele Symbol: Slc30a1^tm1Gka
• Allele Name: targeted mutation 1, Glen K Andrews
• Allele ID: MGI:3056498
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slc30a1^tm1Gka/Slc30a1^tm1Gka	either: (involves: 129S7/SvEvBrd * C57BL/6) or (involves: 129S7/SvEvBrd * CD-1)	MGI:3056540
ht2	Slc30a1^tm1Gka/Slc30a1^+	either: (involves: 129S7/SvEvBrd * C57BL/6) or (involves: 129S7/SvEvBrd * CD-1)	MGI:3056541

Genotype
MGI:3056540

hm1

• Allelic Composition: Slc30a1^tm1Gka/Slc30a1^tm1Gka
• Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6) or (involves: 129S7/SvEvBrd * CD-1)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Slc30a1^tm1Gka/Slc30a1^tm1Gka embryos fail to undergo early morphogenesis

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:93193 )

• embryos die between E9 and E11

• altering maternal zinc levels with either a zinc-deficient or excess zinc diet does not improve survival

embryo

embryonic growth arrest ( J:93193 )

• embryos are smaller than normal on E7, do not appear to grow or differentiate any further by E8, and show no signs of having started morphogenesis by E9

Genotype
MGI:3056541

ht2

• Allelic Composition: Slc30a1^tm1Gka/Slc30a1⁺
• Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6) or (involves: 129S7/SvEvBrd * CD-1)

reproductive system

reduced female fertility ( J:93193 )

♀ • on a zinc deficient diet, heterozygous females produce more embryos with delayed development of digits or more severe craniofacial abnormalities compared to wild-type