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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Igbp1tm1Cbt
targeted mutation 1, Craig B Thompson
MGI:3056510
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Igbp1tm1Cbt/Y
Tg(Lck-cre)1Cwi/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2 MGI:3056653
cn2
 		Igbp1tm1Cbt/Igbp1+
Tg(Lck-cre)1Cwi/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2 MGI:3056654


Genotype
MGI:3056653
cn1
Allelic
Composition		 Igbp1tm1Cbt/Y
Tg(Lck-cre)1Cwi/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igbp1tm1Cbt mutation (0 available); any Igbp1 mutation (9 available)
Tg(Lck-cre)1Cwi mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased thymocyte number ( J:93221 )
• the thymus is depleted of developing T cells and the residual cells are relatively enriched with immature thymocytes
• no peripheral T cells are seen

immune system
decreased thymocyte number ( J:93221 )
• the thymus is depleted of developing T cells and the residual cells are relatively enriched with immature thymocytes
• no peripheral T cells are seen

endocrine/exocrine glands
decreased thymocyte number ( J:93221 )
• the thymus is depleted of developing T cells and the residual cells are relatively enriched with immature thymocytes
• no peripheral T cells are seen




Genotype
MGI:3056654
cn2
Allelic
Composition		 Igbp1tm1Cbt/Igbp1+
Tg(Lck-cre)1Cwi/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igbp1tm1Cbt mutation (0 available); any Igbp1 mutation (9 available)
Tg(Lck-cre)1Cwi mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased thymocyte number ( J:93221 )
• thymocyte numbers are reduced about 60% however peripheral T cell numbers are normal

immune system
decreased thymocyte number ( J:93221 )
• thymocyte numbers are reduced about 60% however peripheral T cell numbers are normal

endocrine/exocrine glands
decreased thymocyte number ( J:93221 )
• thymocyte numbers are reduced about 60% however peripheral T cell numbers are normal




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory