Phenotypes associated with this allele

• Allele Symbol: Lats2^tm1Raz
• Allele Name: targeted mutation 1, Razqallah Hakem
• Allele ID: MGI:3056530
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lats2^tm1Raz/Lats2^tm1Raz	involves: 129P2/OlaHsd * C57BL/6	MGI:3056607

Genotype
MGI:3056607

hm1

• Allelic Composition: Lats2^tm1Raz/Lats2^tm1Raz
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:93191 )

• embryos die between E10.5 - E12.5

cardiovascular system

abnormal heart atrium morphology ( J:93191 )

• atrial hyperplasia with an outgrowth of cells into the common atrial chamber is seen at E9.5 in 25% of embryos

ventricular hypoplasia ( J:93191 )

• at E10.5 ventricular hypoplasia with defective trabeculae and myocardia is seen in 36% of embryos

trabecula carnea hypoplasia ( J:93191 )

• at E10.5 ventricular hypoplasia with defective trabeculae and myocardia is seen in 36% of embryos

hemorrhage ( J:93191 )

• hemorrhaging in the body or head is seen in some embryos at E9.5

hemopericardium ( J:93191 )

• a blood filled pericardium is seen in some embryos at E9.5

cellular

abnormal cell proliferation ( J:93191 )

• MEFs show partial loss of contact inhibition, increased retention of cytoplasmic bridges between neighboring cells, and increased growth in later passages

decreased cell proliferation ( J:93191 )

• BrdU incorporation is decreased in the embryonic conceptus but not extraembryonic tissues in 75% of embryos at E9.5 and decreased or absent in all live embryos at E10.5

chromosome breakage ( J:93191 )

• both MEFs and embryonic cells have more cells with multiple centrosomes and more cells with abnormal chromosome numbers

embryo

embryonic growth retardation ( J:93191 )

• embryos are smaller or developmentally delayed at E9.5

wavy neural tube ( J:93191 )

• an irregular kinked neural tube is seen in some embryos at E9.5

muscle

trabecula carnea hypoplasia ( J:93191 )

• at E10.5 ventricular hypoplasia with defective trabeculae and myocardia is seen in 36% of embryos

nervous system

wavy neural tube ( J:93191 )

• an irregular kinked neural tube is seen in some embryos at E9.5

growth/size/body

embryonic growth retardation ( J:93191 )

• embryos are smaller or developmentally delayed at E9.5

homeostasis/metabolism

hemopericardium ( J:93191 )

• a blood filled pericardium is seen in some embryos at E9.5