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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Crebbptm1.1Ltz
targeted mutation 1.1, Beat Lutz
MGI:3056562
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Crebbptm1.1Ltz/Crebbptm1.1Ltz involves: 129P2/OlaHsd * C57BL/6N MGI:3057010
ht2
Crebbptm1.1Ltz/Crebbp+ involves: 129P2/OlaHsd * C57BL/6N MGI:3057012
ht3
Crebbptm1.1Ltz/Crebbp+ involves: 129P2/OlaHsd * C57BL/6N * CD-1 MGI:3057013


Genotype
MGI:3057010
hm1
Allelic
Composition
Crebbptm1.1Ltz/Crebbptm1.1Ltz
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Crebbptm1.1Ltz mutation (0 available); any Crebbp mutation (100 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:3057012
ht2
Allelic
Composition
Crebbptm1.1Ltz/Crebbp+
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Crebbptm1.1Ltz mutation (0 available); any Crebbp mutation (100 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• reduced survival is seen and this allele could not be backcrossed into C57BL/6N, however backcrossing into CD-1 produces viable offspring

growth/size/body
• mutants are very small compared to wild-type littermates

nervous system
• neurological abnormalities are seen




Genotype
MGI:3057013
ht3
Allelic
Composition
Crebbptm1.1Ltz/Crebbp+
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6N * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Crebbptm1.1Ltz mutation (0 available); any Crebbp mutation (100 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• reduced survival is seen and this allele could not be backcrossed into C57BL/6N, however backcrossing into CD-1 produces viable offspring





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory