Phenotypes associated with this allele

• Allele Symbol: Alcam^tm1Jawe
• Allele Name: targeted mutation 1, Joshua A Weiner
• Allele ID: MGI:3056579
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Alcam^tm1Jawe/Alcam^tm1Jawe	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3057116

Genotype
MGI:3057116

hm1

• Allelic Composition: Alcam^tm1Jawe/Alcam^tm1Jawe
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal retina morphology ( J:93205 )

• in 75% of mutant eyes retinal dysplasia is seen with finger like projections of photoreceptor cells protruding into the outer nuclear layer and/or invagination of the retina without disrupting the cell layers

• dysplasia can be detected on P1

abnormal photoreceptor outer segment morphology ( J:93205 )

• photoreceptor outer segments appear elongated and disorganized

abnormal retina ganglion layer morphology ( J:93205 )

• axons are loosely bundled and occasionally have aberrant trajectories however all exit the optic disc normally

nervous system

abnormal motor neuron innervation pattern ( J:93205 )

• motor neurons are loosely bundled with some axons exiting the bundles at a right angle to the adjacent nerve and ending blindly or forming bridges to neighboring bundles

abnormal photoreceptor outer segment morphology ( J:93205 )

• photoreceptor outer segments appear elongated and disorganized