Phenotypes associated with this allele

• Allele Symbol: Fn1^tm1Ksek
• Allele Name: targeted mutation 1, Kiyotoshi Sekiguchi
• Allele ID: MGI:3056581
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fn1^tm1Ksek/Fn1^tm1Ksek	involves: 129P2/OlaHsd * 129/Sv	MGI:3056921
cx2	Fn1^tm1Ksek/Fn1^tm1Ksek Tg(RIP1-Tag)2Dh/0	involves: 129S4/SvJae * C57BL/6J	MGI:3056922

Genotype
MGI:3056921

hm1

• Allelic Composition: Fn1^tm1Ksek/Fn1^tm1Ksek
• Genetic Background: involves: 129P2/OlaHsd * 129/Sv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

neoplasm ( J:93027 )

N • no difference in tumor growth is seen after injection of C57BL/6 melanoma cells

cardiovascular system

cardiovascular system phenotype ( J:93027 )

N • no difference in physiological or tumor angiogenesis is seen

cellular

decreased fibroblast proliferation ( J:93250 )

• fibroblast growth rate is significantly slower

abnormal extracellular matrix morphology ( J:93250 )

• significantly less fibrinonectin deposited in the extracellular matrix

Genotype
MGI:3056922

cx2

• Allelic Composition: Fn1^tm1Ksek/Fn1^tm1Ksek; Tg(RIP1-Tag)2Dh/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6J

neoplasm

increased carcinoma incidence ( J:93027 )

• the number of angiogenic islets and tumor progression are not different from Tg(RIP1-Tag)2Dh hemizygotes

cardiovascular system

cardiovascular system phenotype ( J:93027 )

N • no difference in tumor angiogenesis is seen