Analysis Tools
neoplasm
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• decreased incidence of induced papillomas
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integument
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• sebocyte size is increased due to a higher lipid content
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• adult mice display altered sebocyte differentiation mediated by an increased proliferation and differentiation of cells located in the periphery of the glands
• stimulation of sebocyte differentiation and turnover occur without alteration of Myc expression in the sebaceous glands
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• adult mice display enlarged sebaceous glands
• sebaceous glands start to enlarge at the age of 4 weeks
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• adult sebaceous glands show a ~1.5-fold increase in the amount of triglycerides, a 2.8-fold increase in wax esters, and a 2.1-fold increase in the amount of cholesterol esters relative to controls
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• mice exhibit progressively increasing sebum production, as shown by Oil red-staining
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greasy coat
(
J:102127
)
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• adult mice display a greasy coat due to increased sebum production and extrusion
• phenotype develops with increasing age and is clearly visible at the age of 2 months
• no cyst development or comedones are observed
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ruffled hair
(
J:102127
)
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• adult mice display ruffled hair
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• accelerated cell turnover
(J:93045)
• normal epidermal stratification
(J:93249)
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• loose appearance of stratum corneum
(J:93249)
• the stratum corneum exhibits more intense Oil red-staining than in wild-type controls
(J:102127)
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• analysis of stratum corneum lipid composition in the tail revealed a 1.4-fold increase in cholesterol and a 1.8-fold increase in total ceramides, with no changes in free fatty acid content relative to controls
• increase in individual ceramides is in the range of 1.6- to 2.3-fold with a notable increase in Cer(EOS)
• precursor lipids glucosylceramides and sphingomyelin are decreased
• increase in ceramides and the decrease in glucosylceramides are not due to an altered sphingolipid biosynthesis
• analysis of lipids covalently bound to the cornified envelope revealed changes in the levels of omega-hydroxylated fatty acids (155% of control) and fatty acids (80% of the control), with no changes in covalently bound Cer(OS)
• the amount of the cornified envelope proteins loricrin and involucrin is not altered
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• slight increase in granular cell size
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• slight increase in the size of keratohyalin granules
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• increased suprabasal cell proliferation
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• adult mice display a significantly increased turnover of sebocytes, as shown by BrdU-labeling
• increased sebocyte proliferation and differentiation occur with no apparent induction of the proliferation-associated keratins K6, K16 or K17 in the sebaceous glands
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endocrine/exocrine glands
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• sebocyte size is increased due to a higher lipid content
|
|
• adult mice display altered sebocyte differentiation mediated by an increased proliferation and differentiation of cells located in the periphery of the glands
• stimulation of sebocyte differentiation and turnover occur without alteration of Myc expression in the sebaceous glands
|
|
• adult mice display enlarged sebaceous glands
• sebaceous glands start to enlarge at the age of 4 weeks
|
|
• adult sebaceous glands show a ~1.5-fold increase in the amount of triglycerides, a 2.8-fold increase in wax esters, and a 2.1-fold increase in the amount of cholesterol esters relative to controls
|
|
• mice exhibit progressively increasing sebum production, as shown by Oil red-staining
|
