Phenotypes associated with this allele

• Allele Symbol: Ctnnd2^tm1Lxin
• Allele Name: targeted mutation 1, Xin Liu
• Allele ID: MGI:3056606
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ctnnd2^tm1Lxin/Ctnnd2^tm1Lxin	involves: 129S4/SvJae * C57BL/6NTac	MGI:3057114

Genotype
MGI:3057114

hm1

• Allelic Composition: Ctnnd2^tm1Lxin/Ctnnd2^tm1Lxin
• Genetic Background: involves: 129S4/SvJae * C57BL/6NTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal contextual conditioning behavior ( J:93226 )

• homozygotes have impaired contextual conditioning behavior

abnormal cued conditioning behavior ( J:93226 )

• homozygotes have impaired auditory conditioning behavior but normal hearing

abnormal spatial learning ( J:93226 )

• homozygotes show no improvement in finding a hidden platform in a water maze over a 2 week training period and swim slower or develop floating behavior in this test, however swimming ability is not impaired

• exploratory and anxiety behaviors are not significantly different from wild typ

impaired coordination ( J:93226 )

• homozygotes fall off a rotating rod sooner but do improve with training

nervous system

abnormal long-term potentiation ( J:93226 )

• long term potentiation is enhanced at high (100 Hz) and very low (1 Hz) frequencies but decreased at low (10 Hz) frequencies