All Phenotypes Tg(Tcrb)93Vbo MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(Tcrb)93Vbo
transgene insertion 93, Harald von Boehmer
MGI:3056727

Summary

10 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	H2^b/H2^b Tcra^tm1Mom/Tcra/Tcrd^{tm1.1(Tcra)Rsky} Tg(Tcrb)93Vbo/?	involves: 129P2/OlaHsd * C57BL/6J * DBA/2J	MGI:3807217
cx2	Tcra^tm1Mom/Tcra/Tcrd^{tm1.1(Tcra)Rsky} H2^b/H2^b Tg(Tcrb)93Vbo/?	involves: 129P2/OlaHsd * C57BL/6J * DBA/2J	MGI:3807222
cx3	H2^b/H2^b Tcra/Tcrd^{tm1.1(Tcra)Rsky}/Tcra/Tcrd^{tm1.1(Tcra)Rsky} Tg(Tcrb)93Vbo/?	involves: 129P2/OlaHsd * C57BL/6J * DBA/2J	MGI:3807223
cx4	H2^b/H2^b Tcra/Tcrd^{tm1.1(Tcra)Rsky}/Tcra/Tcrd^{tm1.1(Tcra)Rsky} Tg(Tcrb)93Vbo/?	involves: 129P2/OlaHsd * C57BL/6J * DBA/2J	MGI:3807224
cx5	H2^b/H2^b Ptcra^tm1Vbo/Ptcra^tm1Vbo Tcra^tm1Mom/Tcra/Tcrd^{tm1.1(Tcra)Rsky} Tg(Tcrb)93Vbo/?	involves: 129P2/OlaHsd * C57BL/6J * DBA/2J	MGI:3807286
cx6	Tcra^tm1Mom/Tcra/Tcrd^{tm1.1(Tcra)Rsky} H2^d/H2^d Ptcra^tm1Vbo/Ptcra^tm1Vbo Tg(Tcrb)93Vbo/?	involves: 129P2/OlaHsd * C57BL/6J * DBA/2J	MGI:3807288
cx7	H2^d/H2^d Tcra/Tcrd^{tm1.1(Tcra)Rsky}/Tcra/Tcrd^{tm1.1(Tcra)Rsky} Tg(Tcrb)93Vbo/0	involves: 129P2/OlaHsd * C57BL/6J * DBA/2J	MGI:3807291
cx8	Prkdc^scid/Prkdc^scid Tg(Tcrb)93Vbo/0	involves: Balb/c * C57BL/Ka * C57BL/Lia * CBA/BrA	MGI:3839250
tg9	Tg(Tcrb)93Vbo/0	involves: C57BL/6 * C57BL/LiA * CBA/BrA	MGI:3839457
tg10	Tg(Tcrb)93Vbo/0	involves: C57BL/LiA * CBA/BrA	MGI:3839243

Allelic Composition	H2^b/H2^b Tcra^tm1Mom/Tcra/Tcrd^{tm1.1(Tcra)Rsky} Tg(Tcrb)93Vbo/?
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J * DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2^b mutation (30 available); any H2 mutation (282 available)
Tcra/Tcrd^{tm1.1(Tcra)Rsky} mutation (0 available); any Tcra mutation (101 available)
Tcra^tm1Mom mutation (6 available); any Tcra mutation (101 available)
Tg(Tcrb)93Vbo mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased thymocyte number ( J:131357 )

• thymocyte number is reduced by about half compared to controls

abnormal T cell differentiation ( J:81564 )

• 18% of lymph node T cells from female mice bearing H2-D^b express the HY-alpha t cell receptor chain

• the majority of T cells in male mice are HYalpha⁺ CD4^-CD8^lo or HYalpha⁺ CD4^-CD8^-

• 5 of 29 thymocytes from H2-D^b background mice not expressing the HY TCR show evidence of receptor editing though the small number of DP and SP thymocytes present suggests this process is inefficient

abnormal negative T cell selection ( J:81564 )

• thymocytes from male mice on a H2-D^b background that express the HY receptor are CD69⁺ and undergoing apoptosis due to negative selection

abnormal double-negative T cell morphology ( J:131357 )

• DN thymocytes of both sexes have premature expression of a T cell receptor (TCR)

• this TCR is specific for the male HY antigen and in many cases there is co-expression of CD25 and CD44

• the percentage of DN cells in the thymus is increased

abnormal double-positive T cell morphology ( J:81564 )

• female mice on a H2-D^b background have almost double the number of DP thymocytes compared to female mice carrying just the Tcrbeta transgene

• the majority of these DP thymocytes do not carry the HY TCR

• male mice on a H2-D^b background have 4% the number of double positive thymocytes

decreased double-positive T cell number ( J:131357 )

• the percentage of DP thymocytes is decreased in these mice

hematopoietic system

decreased thymocyte number ( J:131357 )

• thymocyte number is reduced by about half compared to controls

abnormal T cell differentiation ( J:81564 )

• 18% of lymph node T cells from female mice bearing H2-D^b express the HY-alpha t cell receptor chain

• the majority of T cells in male mice are HYalpha⁺ CD4^-CD8^lo or HYalpha⁺ CD4^-CD8^-

abnormal negative T cell selection ( J:81564 )

• thymocytes from male mice on a H2-D^b background that express the HY receptor are CD69⁺ and undergoing apoptosis due to negative selection

abnormal double-negative T cell morphology ( J:131357 )

• DN thymocytes of both sexes have premature expression of a T cell receptor (TCR)

• this TCR is specific for the male HY antigen and in many cases there is co-expression of CD25 and CD44

• the percentage of DN cells in the thymus is increased

abnormal double-positive T cell morphology ( J:81564 )

• female mice on a H2-D^b background have almost double the number of DP thymocytes compared to female mice carrying just the Tcrbeta transgene

• the majority of these DP thymocytes do not carry the HY TCR

• male mice on a H2-D^b background have 4% the number of double positive thymocytes

decreased double-positive T cell number ( J:131357 )

• the percentage of DP thymocytes is decreased in these mice

endocrine/exocrine glands

decreased thymocyte number ( J:131357 )

• thymocyte number is reduced by about half compared to controls

Allelic Composition	Tcra^tm1Mom/Tcra/Tcrd^{tm1.1(Tcra)Rsky} H2^b/H2^b Tg(Tcrb)93Vbo/?
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J * DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2^b mutation (30 available); any H2 mutation (282 available)
Tcra/Tcrd^{tm1.1(Tcra)Rsky} mutation (0 available); any Tcrd mutation (16 available)
Tcra^tm1Mom mutation (6 available); any Tcra mutation (101 available)
Tg(Tcrb)93Vbo mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased thymocyte number ( J:131357 )

abnormal T cell differentiation ( J:81564 )

• 18% of lymph node T cells from female mice bearing H2-D^b express the HY-alpha t cell receptor chain

• the majority of T cells in male mice are HYalpha⁺ CD4^-CD8^lo or HYalpha⁺ CD4^-CD8^-

• 5 of 29 HY^- thymocytes from H2-D^b background mice have some receptor editing though the small number of DP and SP thymocytes present suggests this process is inefficient

abnormal negative T cell selection ( J:81564 )

• thymocytes from male mice on a H2-D^b background that express the HY receptor are CD69⁺ and undergoing apoptosis due to negative selection

abnormal double-negative T cell morphology ( J:131357 )

• DN thymocytes of both sexes have premature expression of a T cell receptor (TCR)

• this TCR is specific for the male HY antigen and in many cases there is co-expression of CD25 and CD44

• the percentage of DN cells in the thymus is increased

abnormal double-positive T cell morphology ( J:81564 )

• female mice on a H2-D^b background have almost double the number of DP thymocytes compared to female mice carrying just the Tcrbeta transgene

• the majority of these DP thymocytes do not carry the HY TCR

• male mice on a H2-D^b background have 4% the number of double positive thymocytes

decreased double-positive T cell number ( J:131357 )

immune system

decreased thymocyte number ( J:131357 )

abnormal T cell differentiation ( J:81564 )

• 18% of lymph node T cells from female mice bearing H2-D^b express the HY-alpha t cell receptor chain

• the majority of T cells in male mice are HYalpha⁺ CD4^-CD8^lo or HYalpha⁺ CD4^-CD8^-

• 5 of 29 HY^- thymocytes from H2-D^b background mice have some receptor editing though the small number of DP and SP thymocytes present suggests this process is inefficient

abnormal negative T cell selection ( J:81564 )

• thymocytes from male mice on a H2-D^b background that express the HY receptor are CD69⁺ and undergoing apoptosis due to negative selection

abnormal double-negative T cell morphology ( J:131357 )

• DN thymocytes of both sexes have premature expression of a T cell receptor (TCR)

• this TCR is specific for the male HY antigen and in many cases there is co-expression of CD25 and CD44

• the percentage of DN cells in the thymus is increased

abnormal double-positive T cell morphology ( J:81564 )

• female mice on a H2-D^b background have almost double the number of DP thymocytes compared to female mice carrying just the Tcrbeta transgene

• the majority of these DP thymocytes do not carry the HY TCR

• male mice on a H2-D^b background have 4% the number of double positive thymocytes

decreased double-positive T cell number ( J:131357 )

endocrine/exocrine glands

decreased thymocyte number ( J:131357 )

Allelic Composition	H2^b/H2^b Tcra/Tcrd^{tm1.1(Tcra)Rsky}/Tcra/Tcrd^{tm1.1(Tcra)Rsky} Tg(Tcrb)93Vbo/?
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J * DBA/2J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal T cell differentiation ( J:81564 )

• male mice on a H2-D^b background have no distinct double positive or double negative populations in their thymus

abnormal negative T cell selection ( J:81564 )

• almost all thymocytes in male mice on a H2-D^b background undergo negative selection

• receptor editing is unable to rescue these thymocytes

hematopoietic system

abnormal T cell differentiation ( J:81564 )

• male mice on a H2-D^b background have no distinct double positive or double negative populations in their thymus

abnormal negative T cell selection ( J:81564 )

• almost all thymocytes in male mice on a H2-D^b background undergo negative selection

• receptor editing is unable to rescue these thymocytes

Allelic Composition	H2^b/H2^b Tcra/Tcrd^{tm1.1(Tcra)Rsky}/Tcra/Tcrd^{tm1.1(Tcra)Rsky} Tg(Tcrb)93Vbo/?
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J * DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2^b mutation (30 available); any H2 mutation (282 available)
Tcra/Tcrd^{tm1.1(Tcra)Rsky} mutation (0 available); any Tcrd mutation (16 available)
Tg(Tcrb)93Vbo mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal T cell differentiation ( J:81564 )

• male mice on a H2-D^b background have no distinct double positive or double negative populations in their thymus

abnormal negative T cell selection ( J:81564 )

• almost all thymocytes in male mice on a H2-D^b background undergo negative selection

• receptor editing is unable to rescue these thymocytes

immune system

abnormal T cell differentiation ( J:81564 )

• male mice on a H2-D^b background have no distinct double positive or double negative populations in their thymus

abnormal negative T cell selection ( J:81564 )

• almost all thymocytes in male mice on a H2-D^b background undergo negative selection

• receptor editing is unable to rescue these thymocytes

Allelic Composition	H2^b/H2^b Ptcra^tm1Vbo/Ptcra^tm1Vbo Tcra^tm1Mom/Tcra/Tcrd^{tm1.1(Tcra)Rsky} Tg(Tcrb)93Vbo/?
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J * DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2^b mutation (30 available); any H2 mutation (282 available)
Ptcra^tm1Vbo mutation (0 available); any Ptcra mutation (16 available)
Tcra/Tcrd^{tm1.1(Tcra)Rsky} mutation (0 available); any Tcra mutation (101 available)
Tcra^tm1Mom mutation (6 available); any Tcra mutation (101 available)
Tg(Tcrb)93Vbo mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased thymocyte number ( J:131357 )

• thymocyte numbers are reduced by about 3-fold

abnormal T cell differentiation ( J:131357 )

• the presence of HY TCR alleviates the beta-selection block in Ptcra^tm1Vbo homozygotes with higher T cell numbers being found in the thymus and the spleen

• despite the increased numbers of thymocytes, the CD25⁺ thymocyte sub-population still remains very low

hematopoietic system

decreased thymocyte number ( J:131357 )

• thymocyte numbers are reduced by about 3-fold

abnormal T cell differentiation ( J:131357 )

• the presence of HY TCR alleviates the beta-selection block in Ptcra^tm1Vbo homozygotes with higher T cell numbers being found in the thymus and the spleen

• despite the increased numbers of thymocytes, the CD25⁺ thymocyte sub-population still remains very low

endocrine/exocrine glands

decreased thymocyte number ( J:131357 )

• thymocyte numbers are reduced by about 3-fold

Allelic Composition	Tcra^tm1Mom/Tcra/Tcrd^{tm1.1(Tcra)Rsky} H2^d/H2^d Ptcra^tm1Vbo/Ptcra^tm1Vbo Tg(Tcrb)93Vbo/?
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J * DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2^d mutation (23 available); any H2 mutation (282 available)
Ptcra^tm1Vbo mutation (0 available); any Ptcra mutation (16 available)
Tcra/Tcrd^{tm1.1(Tcra)Rsky} mutation (0 available); any Tcrd mutation (16 available)
Tcra^tm1Mom mutation (6 available); any Tcra mutation (101 available)
Tg(Tcrb)93Vbo mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased thymocyte number ( J:131357 )

• thymocyte numbers are reduced by about 3-fold

abnormal T cell differentiation ( J:131357 )

• the presence of HY TCR alleviates the beta-selection block in Ptcra^tm1Vbo homozygotes with higher T cell numbers being found in the thymus and the spleen

• despite the increased numbers of thymocytes, the CD25⁺ thymocyte sub-population still remains very low

immune system

decreased thymocyte number ( J:131357 )

• thymocyte numbers are reduced by about 3-fold

abnormal T cell differentiation ( J:131357 )

• the presence of HY TCR alleviates the beta-selection block in Ptcra^tm1Vbo homozygotes with higher T cell numbers being found in the thymus and the spleen

• despite the increased numbers of thymocytes, the CD25⁺ thymocyte sub-population still remains very low

endocrine/exocrine glands

decreased thymocyte number ( J:131357 )

• thymocyte numbers are reduced by about 3-fold

Allelic Composition	H2^d/H2^d Tcra/Tcrd^{tm1.1(Tcra)Rsky}/Tcra/Tcrd^{tm1.1(Tcra)Rsky} Tg(Tcrb)93Vbo/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J * DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2^d mutation (23 available); any H2 mutation (282 available)
Tcra/Tcrd^{tm1.1(Tcra)Rsky} mutation (0 available); any Tcra mutation (101 available)
Tg(Tcrb)93Vbo mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased thymocyte number ( J:131357 )

• thymocyte numbers are reduced by about 3-fold

abnormal T cell differentiation ( J:131357 )

• the presence of HY TCR alleviates the beta-selection block in Ptcra^tm1Vbo homozygotes with higher T cell numbers being found in the thymus and the spleen

• despite the increased numbers of thymocytes, the CD25⁺ thymocyte sub-population still remains very low

hematopoietic system

decreased thymocyte number ( J:131357 )

• thymocyte numbers are reduced by about 3-fold

abnormal T cell differentiation ( J:131357 )

• the presence of HY TCR alleviates the beta-selection block in Ptcra^tm1Vbo homozygotes with higher T cell numbers being found in the thymus and the spleen

• despite the increased numbers of thymocytes, the CD25⁺ thymocyte sub-population still remains very low

endocrine/exocrine glands

decreased thymocyte number ( J:131357 )

• thymocyte numbers are reduced by about 3-fold

Allelic Composition	Prkdc^scid/Prkdc^scid Tg(Tcrb)93Vbo/0
Genetic Background	involves: Balb/c * C57BL/Ka * C57BL/Lia * CBA/BrA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkdc^scid mutation (179 available); any Prkdc mutation (418 available)
Tg(Tcrb)93Vbo mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal T cell differentiation ( J:111476 )

• thymocytes express high levels of the transgenic TCR-beta chain on their surface that appear to be homodimers

abnormal double-positive T cell morphology ( J:111476 )

• 50% of thymocytes are CD4⁺CD8⁺ compared to scid homozygotes which have no double positive thymocytes

abnormal CD4-positive, alpha beta T cell morphology ( J:111476 )

• T cells are detected in the periphery of these mice compared to the scid homozygotes that lack T cells

• CD4⁺ T cells make up 6.1% of the splenic cells and CD8⁺ make up 0.9% of T cells

abnormal CD8-positive, alpha beta T cell morphology ( J:111476 )

• T cells are detected in the periphery of these mice compared to the scid homozygotes that lack T cells

• CD4⁺ T cells make up 6.1% of the splenic cells and CD8⁺ make up 0.9% of T cells

abnormal single-positive T cell number ( J:111476 )

• small numbers of single-positive thymocytes are in the thymus

• 3% of thymocytes are CD4⁺CD8^- and 7.9% of thymocytes are CD4^-CD8⁺

hematopoietic system

abnormal T cell differentiation ( J:111476 )

• thymocytes express high levels of the transgenic TCR-beta chain on their surface that appear to be homodimers

abnormal double-positive T cell morphology ( J:111476 )

• 50% of thymocytes are CD4⁺CD8⁺ compared to scid homozygotes which have no double positive thymocytes

abnormal CD4-positive, alpha beta T cell morphology ( J:111476 )

• T cells are detected in the periphery of these mice compared to the scid homozygotes that lack T cells

• CD4⁺ T cells make up 6.1% of the splenic cells and CD8⁺ make up 0.9% of T cells

abnormal CD8-positive, alpha beta T cell morphology ( J:111476 )

• T cells are detected in the periphery of these mice compared to the scid homozygotes that lack T cells

• CD4⁺ T cells make up 6.1% of the splenic cells and CD8⁺ make up 0.9% of T cells

abnormal single-positive T cell number ( J:111476 )

• small numbers of single-positive thymocytes are in the thymus

• 3% of thymocytes are CD4⁺CD8^- and 7.9% of thymocytes are CD4^-CD8⁺

Allelic Composition	Tg(Tcrb)93Vbo/0
Genetic Background	involves: C57BL/6 * C57BL/LiA * CBA/BrA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Tcrb)93Vbo mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal CD8-positive, alpha-beta T cell differentiation ( J:66565 )

• 25-33% of peripheral CD8⁺ T cells from female mice recognize HY antigen in the context of H-2D^b compared to less than 1% of wild-type mice

• 7-10% of CD8⁺ T cells from male mice recognize HY antigen in the context of H-2D^b though the affinity for antigen is 3-fold less

• the reduced percentage and binding affinity is also evident in CD8 single-positive male thymocytes

abnormal T cell clonal deletion ( J:66565 )

• the repertoire of T cell receptors (TCR) on T cells differs between male and female transgenic mice

• male mice have preferential deletion of thymocytes bearing TCR with transgenic beta chains that have high-affinity for HY antigen

• HY specific male T cells represent the low-affinity fraction of the corresponding female T cell population

abnormal cytotoxic T cell physiology ( J:66565 )

• female T cells bearing the transgenic TCR-beta chain respond to a 100-fold less HY antigen than transgenic male T cells do

hematopoietic system

abnormal CD8-positive, alpha-beta T cell differentiation ( J:66565 )

• 25-33% of peripheral CD8⁺ T cells from female mice recognize HY antigen in the context of H-2D^b compared to less than 1% of wild-type mice

• 7-10% of CD8⁺ T cells from male mice recognize HY antigen in the context of H-2D^b though the affinity for antigen is 3-fold less

• the reduced percentage and binding affinity is also evident in CD8 single-positive male thymocytes

abnormal T cell clonal deletion ( J:66565 )

• the repertoire of T cell receptors (TCR) on T cells differs between male and female transgenic mice

• male mice have preferential deletion of thymocytes bearing TCR with transgenic beta chains that have high-affinity for HY antigen

• HY specific male T cells represent the low-affinity fraction of the corresponding female T cell population

abnormal cytotoxic T cell physiology ( J:66565 )

• female T cells bearing the transgenic TCR-beta chain respond to a 100-fold less HY antigen than transgenic male T cells do

Allelic Composition	Tg(Tcrb)93Vbo/0
Genetic Background	involves: C57BL/LiA * CBA/BrA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Tcrb)93Vbo mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal T cell morphology ( J:93247 )

• almost all CD4⁺ and CD8⁺ T cells express the transgenic TCR-beta chain

• cytolytic effector functions of T cells are not affected

abnormal T cell receptor beta chain V(D)J recombination ( J:93247 )

• peripheral T cells have rearranged Dbeta1-Jbeta segments that are not recombined with the Vbeta segments

• this "partial" rearrangement occurs with high frequency and is not observed in wild-type T cells

hematopoietic system

abnormal T cell morphology ( J:93247 )

• almost all CD4⁺ and CD8⁺ T cells express the transgenic TCR-beta chain

• cytolytic effector functions of T cells are not affected

abnormal T cell receptor beta chain V(D)J recombination ( J:93247 )

• peripheral T cells have rearranged Dbeta1-Jbeta segments that are not recombined with the Vbeta segments

• this "partial" rearrangement occurs with high frequency and is not observed in wild-type T cells

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