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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(LckNotch1)9Erob
transgene insertion 9, Ellen Robey
MGI:3056811
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		B2mtm1Jae/B2mtm1Jae
Tg(LckNotch1)9Erob/? 		involves: 129S2/SvPas * C57BL/6 * CBA MGI:3834935
tg2
 		Tg(LckNotch1)9Erob/? involves: C57BL/6 * CBA/J MGI:3834934


Genotype
MGI:3834935
cx1
Allelic
Composition		 B2mtm1Jae/B2mtm1Jae
Tg(LckNotch1)9Erob/?
Genetic
Background		 involves: 129S2/SvPas * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
B2mtm1Jae mutation (8 available); any B2m mutation (122 available)
Tg(LckNotch1)9Erob mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased CD8-positive, alpha-beta T cell number ( J:93005 )
• mice have 2-fold more mature single-positive CD8 thymocytes than wild-type mice and over a 1000-fold more than fold in B2mtm1Jae homozygote controls
• in the periphery, CD8+ T cells make up 2% of the lymph node population compared to less than 0.1% for B2mtm1Jae homozygote controls
lymph node hypoplasia ( J:93005 )
• lymph node cellularity is 25% that of controls, with a normal ratio between CD4+ and CD8+ T cells

hematopoietic system
increased CD8-positive, alpha-beta T cell number ( J:93005 )
• mice have 2-fold more mature single-positive CD8 thymocytes than wild-type mice and over a 1000-fold more than fold in B2mtm1Jae homozygote controls
• in the periphery, CD8+ T cells make up 2% of the lymph node population compared to less than 0.1% for B2mtm1Jae homozygote controls




Genotype
MGI:3834934
tg2
Allelic
Composition		 Tg(LckNotch1)9Erob/?
Genetic
Background		 involves: C57BL/6 * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(LckNotch1)9Erob mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal thymus cell ratio ( J:93005 )
• there is a 15-fold change in the ratio of single positive CD4 versus CD8 thymocyte production
increased T cell derived lymphoma incidence ( J:93005 )
• older mice can develop thymomas consisting of thymocytes with a CD8+CD4lowTCRlow morphology
abnormal CD8-positive, alpha-beta T cell differentiation ( J:93005 )
• thymocyte development is skewed towards development into the CD8 T cell lineage
• mutant bone marrow can support CD8 T cell development when transferred to class I MHC or class II MHC-deficient host mice
• however, mutant bone marrow can not support CD8 T cell development in hosts deficient for both class I and class II MHC
decreased CD4-positive, alpha-beta T cell number ( J:93005 )
• while decreases in CD4 single positive thymocyte number are inconsistent, kinetic studies demonstrate a 5-fold decrease in CD4 single-positive thymocyte production compared to control
increased CD8-positive, alpha-beta T cell number ( J:93005 )
• there is a 10-fold increase in the number and percentage of mature CD8 single-positive thymocytes compared to controls
• production of these single-positive CD8 thymocytes is increased 3-fold

neoplasm
increased T cell derived lymphoma incidence ( J:93005 )
• older mice can develop thymomas consisting of thymocytes with a CD8+CD4lowTCRlow morphology

hematopoietic system
abnormal thymus cell ratio ( J:93005 )
• there is a 15-fold change in the ratio of single positive CD4 versus CD8 thymocyte production
increased T cell derived lymphoma incidence ( J:93005 )
• older mice can develop thymomas consisting of thymocytes with a CD8+CD4lowTCRlow morphology
abnormal CD8-positive, alpha-beta T cell differentiation ( J:93005 )
• thymocyte development is skewed towards development into the CD8 T cell lineage
• mutant bone marrow can support CD8 T cell development when transferred to class I MHC or class II MHC-deficient host mice
• however, mutant bone marrow can not support CD8 T cell development in hosts deficient for both class I and class II MHC
decreased CD4-positive, alpha-beta T cell number ( J:93005 )
• while decreases in CD4 single positive thymocyte number are inconsistent, kinetic studies demonstrate a 5-fold decrease in CD4 single-positive thymocyte production compared to control
increased CD8-positive, alpha-beta T cell number ( J:93005 )
• there is a 10-fold increase in the number and percentage of mature CD8 single-positive thymocytes compared to controls
• production of these single-positive CD8 thymocytes is increased 3-fold

endocrine/exocrine glands
abnormal thymus cell ratio ( J:93005 )
• there is a 15-fold change in the ratio of single positive CD4 versus CD8 thymocyte production
increased T cell derived lymphoma incidence ( J:93005 )
• older mice can develop thymomas consisting of thymocytes with a CD8+CD4lowTCRlow morphology




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory