Phenotypes associated with this allele

• Allele Symbol: Tg(CMV-rtTA)4Bjd
• Allele Name: transgene insertion 4, Hermann Bujard
• Allele ID: MGI:3056891
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Col1a1^tm8(tetO-GFP/RNAi:Rpa3)Slowe/Col1a1^+ Tg(CMV-rtTA)4Bjd/0	involves: 129S4/SvJae * C57BL/6 * NMRI	MGI:5000005
cx2	Col1a1^tm8(tetO-GFP/RNAi:Rpa3)Slowe/Col1a1^+ Gt(ROSA)26Sor^tm1(rtTA*M2)Jae/Gt(ROSA)26Sor^+ Tg(CMV-rtTA)4Bjd/0	involves: 129S4/SvJae * C57BL/6 * NMRI	MGI:5000006
cx3	Col1a1^tm10(tetO*-RFP/RNAi:Rpa3)Slowe/Col1a1^+ Gt(ROSA)26Sor^tm1(rtTA*M2)Jae/Gt(ROSA)26Sor^+ Tg(CMV-rtTA)4Bjd/0	involves: 129S4/SvJae * C57BL/6 * NMRI	MGI:5000009
cx4	Col1a1^tm11(tetO*-RFP/RNAi:Rpa3)Slowe/Col1a1^+ Gt(ROSA)26Sor^tm1(rtTA*M2)Jae/Gt(ROSA)26Sor^+ Tg(CMV-rtTA)4Bjd/0	involves: 129S4/SvJae * C57BL/6 * NMRI	MGI:5000014

Genotype
MGI:5000005

cx1

• Allelic Composition: Col1a1^{tm8(tetO-GFP/RNAi:Rpa3)Slowe}/Col1a1⁺; Tg(CMV-rtTA)4Bjd/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * NMRI

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:171348 )

• most mice treated with doxycycline between 5 and 10 weeks of age die prematurely

growth/size/body

weight loss ( J:171348 )

• in doxycycline-treated mice

cellular

abnormal cell cycle ( J:171348 )

• doxycycline-treated mice exhibit cell cycle arrest in the liver, spleen, and intestine unlike control mice

Genotype
MGI:5000006

cx2

• Allelic Composition: Col1a1^{tm8(tetO-GFP/RNAi:Rpa3)Slowe}/Col1a1⁺; Gt(ROSA)26Sor^{tm1(rtTA*M2)Jae}/Gt(ROSA)26Sor⁺; Tg(CMV-rtTA)4Bjd/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * NMRI

mortality/aging

premature death ( J:171348 )

• half of mice treated with doxycycline between 5 and 10 weeks of age die prematurely

growth/size/body

weight loss ( J:171348 )

• in doxycycline-treated mice

cellular

abnormal cell cycle ( J:171348 )

• doxycycline-treated mice exhibit cell cycle arrest in the liver, spleen, and intestine unlike control mice

Genotype
MGI:5000009

cx3

• Allelic Composition: Col1a1^{tm10(tetO*-RFP/RNAi:Rpa3)Slowe}/Col1a1⁺; Gt(ROSA)26Sor^{tm1(rtTA*M2)Jae}/Gt(ROSA)26Sor⁺; Tg(CMV-rtTA)4Bjd/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * NMRI

mortality/aging

premature death ( J:171348 )

• most mice treated with doxycycline between 5 and 10 weeks of age die prematurely

growth/size/body

weight loss ( J:171348 )

• in doxycycline-treated mice

Genotype
MGI:5000014

cx4

• Allelic Composition: Col1a1^{tm11(tetO*-RFP/RNAi:Rpa3)Slowe}/Col1a1⁺; Gt(ROSA)26Sor^{tm1(rtTA*M2)Jae}/Gt(ROSA)26Sor⁺; Tg(CMV-rtTA)4Bjd/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * NMRI

mortality/aging

premature death ( J:171348 )

• most mice treated with doxycycline between 5 and 10 weeks of age die prematurely

growth/size/body

weight loss ( J:171348 )

• in doxycycline-treated mice