Phenotypes associated with this allele

• Allele Symbol: Slc6a9^tm1.1Blt
• Allele Name: targeted mutation 1.1, H Bluethmann
• Allele ID: MGI:3056923
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slc6a9^tm1.1Blt/Slc6a9^tm1.1Blt	C57BL/6J-Slc6a9^tm1.1Blt	MGI:3057117
ht2	Slc6a9^tm1.1Blt/Slc6a9^+	C57BL/6J-Slc6a9^tm1.1Blt	MGI:3057118

Genotype
MGI:3057117

hm1

• Allelic Composition: Slc6a9^tm1.1Blt/Slc6a9^tm1.1Blt
• Genetic Background: C57BL/6J-Slc6a9^tm1.1Blt

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:93288 )

• no live-born homozygotes were recovered from heterozygous matings

Genotype
MGI:3057118

ht2

• Allelic Composition: Slc6a9^tm1.1Blt/Slc6a9⁺
• Genetic Background: C57BL/6J-Slc6a9^tm1.1Blt

behavior/neurological

behavior/neurological phenotype ( J:93288 )

N • heterozygous mice exhibit no gross behavioral phenotype

nervous system

nervous system phenotype ( J:93288 )

N • brains of heterozygous mice appear grossly normal histologically

enhanced NMDA-mediated synaptic currents ( J:93288 )

• the NMDA/AMPA response ratio - i.e., the peak-amplitude ratio of NMDA- to AMPA-receptor mediated evoked excitatory postsynaptic currents (EPSCs) - of CA1 pyramidal neurons in hippocampal slices from 17-24 day old heterozygous mutants is 36% greater than in wild-type slices

• the frequency and amplitude of AMPA evoked and spontaneous, miniature excitatory postsynaptic currents are unaltered, indicating the enhanced NMDA/AMPA ratio is due to increased NMDA responsiveness