About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Igh-6/Igh-V281)3Jwt
transgene insertion 3, James W Thomas
MGI:3056939
Summary 3 genotypes


Genotype
MGI:3623592
cx1
Allelic
Composition		 Ighmtm1Cgn/Ighmtm1Cgn
Tg(Igh-6/Igh-V281)3Jwt/0
Genetic
Background		 NOD.Cg-Ighmtm1Cgn Tg(Igh-6/Igh-V281)3Jwt
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ighmtm1Cgn mutation (17 available); any Ighm mutation (55 available)
Tg(Igh-6/Igh-V281)3Jwt mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
insulitis ( J:91865 )
• by 40 weeks, pancreata of transgenic mice show extensive infiltrates; at 6 weeks, in the early prediabetic period, the incidence of infiltration is 40-50% slightly less than mice carrying the V281 transgene; the percentage of islets infiltrated is slightly greater in transgenic mice heterozygous for Igh-6

immune system
insulitis ( J:91865 )
• by 40 weeks, pancreata of transgenic mice show extensive infiltrates; at 6 weeks, in the early prediabetic period, the incidence of infiltration is 40-50% slightly less than mice carrying the V281 transgene; the percentage of islets infiltrated is slightly greater in transgenic mice heterozygous for Igh-6




Genotype
MGI:3623593
cx2
Allelic
Composition		 Ighmtm1Cgn/Ighm+
Tg(Igh-6/Igh-V281)3Jwt/0
Genetic
Background		 NOD.Cg-Ighmtm1Cgn Tg(Igh-6/Igh-V281)3Jwt
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ighmtm1Cgn mutation (17 available); any Ighm mutation (55 available)
Tg(Igh-6/Igh-V281)3Jwt mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
insulitis ( J:91865 )
• the percentage of islets infiltrated is slightly greater in transgenic mice heterozygous for Igh-6

immune system
insulitis ( J:91865 )
• the percentage of islets infiltrated is slightly greater in transgenic mice heterozygous for Igh-6

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
type 1 diabetes mellitus DOID:9744 OMIM:222100
 J:91865




Genotype
MGI:3623591
tg3
Allelic
Composition		 Tg(Igh-6/Igh-V281)3Jwt/0
Genetic
Background		 NOD.B6-Tg(Igh-6/Igh-V281)3Jwt
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Igh-6/Igh-V281)3Jwt mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
insulitis ( J:91865 )
• by 40 weeks, pancreata of transgenic mice show extensive infiltrates

immune system
insulitis ( J:91865 )
• by 40 weeks, pancreata of transgenic mice show extensive infiltrates
decreased susceptibility to autoimmune diabetes ( J:91865 )
• transgenic mice are protected from developing diabetes; 16% develop diabetes by 40 weeks

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
type 1 diabetes mellitus DOID:9744 OMIM:222100
 J:91865




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
06/12/2024
MGI 6.13 		The Jackson Laboratory