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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Igh-6/Igh-V281)3Jwt
transgene insertion 3, James W Thomas
MGI:3056939
Summary 3 genotypes


Genotype
MGI:3623592
cx1
Allelic
Composition		 Ighmtm1Cgn/Ighmtm1Cgn
Tg(Igh-6/Igh-V281)3Jwt/0
Genetic
Background		 NOD.Cg-Ighmtm1Cgn Tg(Igh-6/Igh-V281)3Jwt
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ighmtm1Cgn mutation (17 available); any Ighm mutation (56 available)
Tg(Igh-6/Igh-V281)3Jwt mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
insulitis ( J:91865 )
• by 40 weeks, pancreata of transgenic mice show extensive infiltrates; at 6 weeks, in the early prediabetic period, the incidence of infiltration is 40-50% slightly less than mice carrying the V281 transgene; the percentage of islets infiltrated is slightly greater in transgenic mice heterozygous for Igh-6

immune system
insulitis ( J:91865 )
• by 40 weeks, pancreata of transgenic mice show extensive infiltrates; at 6 weeks, in the early prediabetic period, the incidence of infiltration is 40-50% slightly less than mice carrying the V281 transgene; the percentage of islets infiltrated is slightly greater in transgenic mice heterozygous for Igh-6




Genotype
MGI:3623593
cx2
Allelic
Composition		 Ighmtm1Cgn/Ighm+
Tg(Igh-6/Igh-V281)3Jwt/0
Genetic
Background		 NOD.Cg-Ighmtm1Cgn Tg(Igh-6/Igh-V281)3Jwt
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ighmtm1Cgn mutation (17 available); any Ighm mutation (56 available)
Tg(Igh-6/Igh-V281)3Jwt mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
insulitis ( J:91865 )
• the percentage of islets infiltrated is slightly greater in transgenic mice heterozygous for Igh-6

immune system
insulitis ( J:91865 )
• the percentage of islets infiltrated is slightly greater in transgenic mice heterozygous for Igh-6

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
type 1 diabetes mellitus DOID:9744 OMIM:222100
 J:91865




Genotype
MGI:3623591
tg3
Allelic
Composition		 Tg(Igh-6/Igh-V281)3Jwt/0
Genetic
Background		 NOD.B6-Tg(Igh-6/Igh-V281)3Jwt
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Igh-6/Igh-V281)3Jwt mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
insulitis ( J:91865 )
• by 40 weeks, pancreata of transgenic mice show extensive infiltrates

immune system
insulitis ( J:91865 )
• by 40 weeks, pancreata of transgenic mice show extensive infiltrates
decreased susceptibility to autoimmune diabetes ( J:91865 )
• transgenic mice are protected from developing diabetes; 16% develop diabetes by 40 weeks

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
type 1 diabetes mellitus DOID:9744 OMIM:222100
 J:91865




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory