Phenotypes associated with this allele

• Allele Symbol: Tg(DBH-Gal)1923Stei
• Allele Name: transgene insertion 1923, Robert A Steiner
• Allele ID: MGI:3057122
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(DBH-Gal)1923Stei/0	B6.Cg-Tg(DBH-Gal)1923Stei	MGI:3718126
tg2	Tg(DBH-Gal)1923Stei/0	involves: C57BL/6 * SJL	MGI:3718404

Genotype
MGI:3718126

tg1

• Allelic Composition: Tg(DBH-Gal)1923Stei/0
• Genetic Background: B6.Cg-Tg(DBH-Gal)1923Stei

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased susceptibility to xenobiotic induced morbidity/mortality ( J:77625 )

• 1/6 mice die after 30 mg/kg kainic acid treatment compared to 5/6 wild-type mice

behavior/neurological

abnormal olfactory discrimination memory ( J:102197 )

• transgenic mice show no preference for a previously cued food odor 24 hours after exposure, whereas wild-type show significant preference for cued food odor

abnormal spatial learning ( J:102197 )

• mice show significant impairment compared to controls, failing to display selective search during the probe trial when the platform is removed in the Morris water maze; controls show greater preference for the target quadrant at 8 and 16 months

• mutants have normal performance in the visible and hidden platform trials, but show inability to remember navigational cues needed to solve spatial navigation problem

seizures ( J:77625 )

• after 60 minutes of perforant path stimulation, only brief seizure activity is seen in transgenic mice compared to wild-type controls; last seizure occurs 25 minutes after PPS

decreased susceptibility to pharmacologically induced seizures ( J:77625 )

• 30 mg/kg kainic acid treatment induces a few stage 5 seizures, resulting in death of 1/6 animals, but wild-type animals exhibit severe seizures, with death occurring in 5/6 animals within 30 minutes

• pentylene tetrazol (PTZ) treatment results in less severe seizures than those induced by kainic acid

• galanin agonist treatment reduces the latency and severity of PTZ-induced seizures

nervous system

seizures ( J:77625 )

• after 60 minutes of perforant path stimulation, only brief seizure activity is seen in transgenic mice compared to wild-type controls; last seizure occurs 25 minutes after PPS

decreased susceptibility to pharmacologically induced seizures ( J:77625 )

• 30 mg/kg kainic acid treatment induces a few stage 5 seizures, resulting in death of 1/6 animals, but wild-type animals exhibit severe seizures, with death occurring in 5/6 animals within 30 minutes

• pentylene tetrazol (PTZ) treatment results in less severe seizures than those induced by kainic acid

• galanin agonist treatment reduces the latency and severity of PTZ-induced seizures

abnormal hippocampus morphology ( J:77625 )

• after kainic acid treatment, the surviving transgenic mice display mild injury to the hippocampus, compared to the wild-type survivor which displayed moderate injury in the CA1, CA3, and hilus

abnormal cholinergic neuron morphology ( J:102197 )

• disappearance of detectable cholinergic neurons is observed

reduced long-term potentiation ( J:77625 )

• mutants show faster LTP decay compared to wild-type

homeostasis/metabolism

decreased susceptibility to xenobiotic induced morbidity/mortality ( J:77625 )

• 1/6 mice die after 30 mg/kg kainic acid treatment compared to 5/6 wild-type mice

Genotype
MGI:3718404

tg2

• Allelic Composition: Tg(DBH-Gal)1923Stei/0
• Genetic Background: involves: C57BL/6 * SJL

behavior/neurological

increased thermal nociceptive threshold ( J:100969 )

• paw withdrawal and tail flick latency are elevated compared to wild-type controls in response to radiant heat