Phenotypes associated with this allele

• Allele Symbol: Tg(PDGFB-APP)5Lms
• Allele Name: transgene insertion 5, Lennart Mucke
• Allele ID: MGI:3057135
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Psen1^tm4.1Shn/Psen1^+ Tg(PDGFB-APP)5Lms/0	involves: 129 * C57BL/6 * C57BL/6J * DBA/2	MGI:5754380
tg2	Tg(PDGFB-APP)5Lms/?	involves: C57BL/6 * DBA/2	MGI:3777106

Genotype
MGI:5754380

cx1

• Allelic Composition: Psen1^tm4.1Shn/Psen1⁺; Tg(PDGFB-APP)5Lms/0
• Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:219929 )

N • no amyloid plaque deposition is seen in the cerebral cortex even at 18 months of age

Genotype
MGI:3777106

tg2

• Allelic Composition: Tg(PDGFB-APP)5Lms/?
• Genetic Background: involves: C57BL/6 * DBA/2

nervous system

nervous system phenotype ( J:62290 )

N • no amyloid plaques are detected by immunohistochemistry up to the age of 24 months

amyloid beta deposits ( J:137264 )

• significantly elevated beta amyloid

• a further 3 fold increase in amyloid beta 40 but not amyloid beta 42 when placed on a high fat diet

neurodegeneration ( J:62290 )

• neurodegeneration is indicated by an age dependent decrease in density of synaptophysin-immunoreactive presynaptic terminals

homeostasis/metabolism

amyloid beta deposits ( J:137264 )

• significantly elevated beta amyloid

• a further 3 fold increase in amyloid beta 40 but not amyloid beta 42 when placed on a high fat diet