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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(TcraAI4)1Dvs
transgene insertion 1, David V Serreze
MGI:3057179
Summary 7 genotypes


Genotype
MGI:4868729
cx1
Allelic
Composition		 H2g7/H2g7
Tg(TcraAI4)1Dvs/0
Tg(TcrbAI4)1Dvs/0
Genetic
Background		 B6.NOD-(D17Mit21-D17Mit10) Tg(TcraAI4)1Dvs Tg(TcrbAI4)1Dvs
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2g7 mutation (24 available); any H2 mutation (282 available)
Tg(TcraAI4)1Dvs mutation (3 available)
Tg(TcrbAI4)1Dvs mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased susceptibility to autoimmune diabetes ( J:167508 )
• Background Sensitivity: although negative selection of these transgenic thymocytes is stronger on the B6 than NOD background, there is earlier onset and greater penetrance of diabetes in females on the B6 background
• Background Sensitivity: compared with those on the NOD background, on the B6 background these TCR transgenic T cells have greater proliferative response to antigen presentation and display more potent killing of pancreatic islet cells




Genotype
MGI:3618703
cx2
Allelic
Composition		 B2mtm1Unc/B2mtm1Unc
Tg(TcraAI4)1Dvs/0
Tg(TcrbAI4)1Dvs/0
Genetic
Background		 NOD.Cg-B2mtm1Unc Tg(TcraAI4)1Dvs Tg(TcrbAI4)1Dvs
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
B2mtm1Unc mutation (38 available); any B2m mutation (122 available)
Tg(TcraAI4)1Dvs mutation (3 available)
Tg(TcrbAI4)1Dvs mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal CD8-positive, alpha beta T cell morphology ( J:93553 )
• mice exhibit a complete absence of CD8 T cells expressing the transgenes but transgene-expressing CD4 T cells are present

immune system
abnormal CD8-positive, alpha beta T cell morphology ( J:93553 )
• mice exhibit a complete absence of CD8 T cells expressing the transgenes but transgene-expressing CD4 T cells are present
decreased susceptibility to autoimmune diabetes ( J:93553 )
• B2m-deficient female transgenic NOD mice are completely diabetes resistant compared to transgenic NOD controls

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
NOT type 1 diabetes mellitus DOID:9744 OMIM:222100
 J:93553




Genotype
MGI:3618705
cx3
Allelic
Composition		 Cd4tm1Knw/Cd4tm1Knw
Tg(TcraAI4)1Dvs/0
Tg(TcrbAI4)1Dvs/0
Genetic
Background		 NOD.Cg-Cd4tm1Knw Tg(TcraAI4)1Dvs Tg(TcrbAI4)1Dvs
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd4tm1Knw mutation (3 available); any Cd4 mutation (85 available)
Tg(TcraAI4)1Dvs mutation (3 available)
Tg(TcrbAI4)1Dvs mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased susceptibility to autoimmune diabetes ( J:93553 )
• transgene-expressing female mice develop IDDM with an onset of about 7 weeks of age, whereas CD4-null NOD mice are resistant (no IDDM by 30 weeks of age)

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
type 1 diabetes mellitus DOID:9744 OMIM:222100
 J:93553




Genotype
MGI:3618702
cx4
Allelic
Composition		 Prkdcscid/Prkdcscid
Tg(TcraAI4)1Dvs/0
Tg(TcrbAI4)1Dvs/0
Genetic
Background		 NOD.Cg-Prkdcscid Tg(TcraAI4)1Dvs Tg(TcrbAI4)1Dvs
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkdcscid mutation (179 available); any Prkdc mutation (418 available)
Tg(TcraAI4)1Dvs mutation (3 available)
Tg(TcrbAI4)1Dvs mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal CD4-positive, alpha beta T cell morphology ( J:93553 )
• mice exhibit a complete absence of CD4 T cells expressing the transgenes but transgene-expressing CD8 T cells are present

immune system
abnormal CD4-positive, alpha beta T cell morphology ( J:93553 )
• mice exhibit a complete absence of CD4 T cells expressing the transgenes but transgene-expressing CD8 T cells are present
increased susceptibility to autoimmune diabetes ( J:93553 )
• female NOD.scid transgenic mice display accerlerated diabetes development compared to standard NOD females

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
type 1 diabetes mellitus DOID:9744 OMIM:222100
 J:93553




Genotype
MGI:3618788
cx5
Allelic
Composition		 Rag1tm1Mom/Rag1tm1Mom
Tg(TcraAI4)1Dvs/0
Tg(TcrbAI4)1Dvs/0
Genetic
Background		 NOD.Cg-Rag1tm1Mom Tg(TcraAI4)1Dvs Tg(TcrbAI4)1Dvs/Dvs
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag1tm1Mom mutation (49 available); any Rag1 mutation (123 available)
Tg(TcraAI4)1Dvs mutation (3 available)
Tg(TcrbAI4)1Dvs mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased susceptibility to autoimmune diabetes ( J:94192 )
• females have a greatly increased rate of diabetes development compared to non-transgenic NOD controls (100% incidence by 6 weeks of age)

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
type 1 diabetes mellitus DOID:9744 OMIM:222100
 J:94192




Genotype
MGI:3618699
cx6
Allelic
Composition		 Tg(TcraAI4)1Dvs/0
Tg(TcrbAI4)1Dvs/0
Genetic
Background		 NOD-Tg(TcraAI4)1Dvs Tg(TcrbAI4)1Dvs
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(TcraAI4)1Dvs mutation (3 available)
Tg(TcrbAI4)1Dvs mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal CD4-positive, alpha beta T cell morphology ( J:93553 )
• T cells expressing the transgenes comprise ~35% of the total peripheral blood lymphocyte population, a significant fraction of these T cells resides in the CD4 lineage rather than in the expected CD8 lineage
abnormal CD8-positive, alpha beta T cell morphology ( J:94192 )
• only transgene expressing CD8+ T cells from primary splenocytes expand when cultured in presence of islets from NOD-scid donors
abnormal cytotoxic T cell physiology ( J:94192 )
• transgenic CTLs generated in culture on islets exhibit cytotoxicity against a NOD-derived beta cell adenoma cell line and this is augmented when adenoma cells are pretreated with IFNG
increased susceptibility to autoimmune diabetes ( J:94192 )
• female NOD mice carrying both transgenes develop IDDM at a greatly increased rate compared to nontransgenic controls with disease appearing as early as 3 weeks of age

hematopoietic system
abnormal CD4-positive, alpha beta T cell morphology ( J:93553 )
• T cells expressing the transgenes comprise ~35% of the total peripheral blood lymphocyte population, a significant fraction of these T cells resides in the CD4 lineage rather than in the expected CD8 lineage
abnormal CD8-positive, alpha beta T cell morphology ( J:94192 )
• only transgene expressing CD8+ T cells from primary splenocytes expand when cultured in presence of islets from NOD-scid donors
abnormal cytotoxic T cell physiology ( J:94192 )
• transgenic CTLs generated in culture on islets exhibit cytotoxicity against a NOD-derived beta cell adenoma cell line and this is augmented when adenoma cells are pretreated with IFNG

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
type 1 diabetes mellitus DOID:9744 OMIM:222100
 J:93553




Genotype
MGI:3618697
tg7
Allelic
Composition		 Tg(TcraAI4)1Dvs/0
Genetic
Background		 NOD-Tg(TcraAI4)1Dvs
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(TcraAI4)1Dvs mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal CD4-positive, alpha beta T cell morphology ( J:93553 )
• T cells expressing the transgene comprise ~30% of the total peripheral blood lymphocyte population, a significantly higher fraction of these T cells resides in the CD4 lineage rather than in the expected CD8 lineage

immune system
abnormal CD4-positive, alpha beta T cell morphology ( J:93553 )
• T cells expressing the transgene comprise ~30% of the total peripheral blood lymphocyte population, a significantly higher fraction of these T cells resides in the CD4 lineage rather than in the expected CD8 lineage
increased susceptibility to autoimmune diabetes ( J:93553 )
• female NOD mice carrying this transgene develop IDDM at a slightly but not significantly accelerated rate compared to nontransgenic NOD controls

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
type 1 diabetes mellitus DOID:9744 OMIM:222100
 J:93553




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory