Phenotypes associated with this allele

• Allele Symbol: Tg(GFAP-APOE_i2)14Hol
• Allele Name: transgene insertion 14, David M Holtzman
• Allele ID: MGI:3057185
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Apoe^tm1Unc/Apoe^tm1Unc Tg(APPV717F)109Ili/0 Tg(GFAP-APOE_i2)14Hol/0	involves: 129P2/OlaHsd * C57BL/6 * CBA	MGI:3784387

Genotype
MGI:3784387

cx1

• Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc; Tg(APPV717F)109Ili/0; Tg(GFAP-APOE_i2)14Hol/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

amyloid beta deposits ( J:127846 )

• 66% of mice exhibit plaques after 18 months

• mice exhibit plaques in the stratum oriens and radiatum of the hippocampus and hilus of the dentate gyrus but no the molecular layer of the dentate gyrus

• however, no fibrillar plaques are detected

homeostasis/metabolism

amyloid beta deposits ( J:127846 )

• 66% of mice exhibit plaques after 18 months

• mice exhibit plaques in the stratum oriens and radiatum of the hippocampus and hilus of the dentate gyrus but no the molecular layer of the dentate gyrus

• however, no fibrillar plaques are detected