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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(GFAP-APOE_i3)37Hol
transgene insertion 37, David M Holtzman
MGI:3057188
Summary 4 genotypes


Genotype
MGI:3784381
cx1
Allelic
Composition		 Apoetm1Unc/Apoetm1Unc
Tg(GFAP-APOE_i3)37Hol/0
Genetic
Background		 B6.Cg-Apoetm1Unc Tg(GFAP-APOE_i3)37Hol
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoetm1Unc mutation (33 available); any Apoe mutation (158 available)
Tg(GFAP-APOE_i3)37Hol mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal response to new environment ( J:71062 )
• mice consume food slower in a new environment than Tg(GFAP-APOE_i4)#Hol Apoetm1Unc/Apoetm1Unc and wild-type mice
• mice require more time to habituate to a novel environment compared to wild-type mice
• mice are less reluctant than wild-type mice to move into an open area
abnormal spatial learning ( J:71062 )
• at 14 to 17 months of age, mice perform better than Tg(GFAP-APOE_i4)#Hol Apoetm1Unc/Apoetm1Unc and wild-type mice in a rotating holeboard test
abnormal fear/anxiety-related behavior ( J:71062 )
• mice exhibit increased protected risk assessment behaviors in an elevated plus maze compared to wild-type mice
decreased startle reflex ( J:71062 )
• compared to wild-type mice
abnormal stationary movement ( J:71062 )
• mice exhibit increased numbers of fine movement (not related to ambulation) compared to wild-type mice
abnormal locomotor behavior ( J:71062 )
• mice spend less time than wild-type mice in the center of an open field




Genotype
MGI:3784303
cx2
Allelic
Composition		 Apoetm1Unc/Apoetm1Unc
Tg(GFAP-APOE_i3)37Hol/0
Genetic
Background		 B6.Cg-Tg(GFAP-APOE_i3)37Hol Apoetm1Unc/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoetm1Unc mutation (33 available); any Apoe mutation (158 available)
Tg(GFAP-APOE_i3)37Hol mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal axon extension ( J:93487 )
• in vitro, neuron outgrowth is faster than in Apoetm1Unc/Apoetm1Unc Tg(GFAP-APOE_i4)22Hol neurons
• in vitro, neurite length is longer than in Apoetm1Unc/Apoetm1Unc Tg(GFAP-APOE_i4)22Hol neurons
• however, neurite outgrowth rate is equivalent to in Apoetm1Unc/Apoetm1Unc Tg(GFAP-APOE_i4)22Hol neurons when neurons are treated with RAP or anti-LRP IgG
abnormal astrocyte physiology ( J:58019 )
• the ratio of lipid to Apoe in HDL particles secreted from astrocytes is lower than in wild-type astrocytes but higher than in Apoetm1Unc homozygotes

cellular
abnormal axon extension ( J:93487 )
• in vitro, neuron outgrowth is faster than in Apoetm1Unc/Apoetm1Unc Tg(GFAP-APOE_i4)22Hol neurons
• in vitro, neurite length is longer than in Apoetm1Unc/Apoetm1Unc Tg(GFAP-APOE_i4)22Hol neurons
• however, neurite outgrowth rate is equivalent to in Apoetm1Unc/Apoetm1Unc Tg(GFAP-APOE_i4)22Hol neurons when neurons are treated with RAP or anti-LRP IgG




Genotype
MGI:3784384
cx3
Allelic
Composition		 Apoetm1Unc/Apoetm1Unc
Tg(APPV717F)109Ili/0
Tg(GFAP-APOE_i3)37Hol/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoetm1Unc mutation (33 available); any Apoe mutation (158 available)
Tg(APPV717F)109Ili mutation (0 available)
Tg(GFAP-APOE_i3)37Hol mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
amyloid beta deposits ( J:127846 , J:133058 )
• by 15 to 18 months, 31% of mice exhibit plaques in the hippocampus (J:127846)
• the amount of amyloid deposited is less than in Tg(APPV717F)109Ili Tg(GFAP-APOE_i4)#Hol Apoetm1Unc/Apoetm1Unc and much less than in Tg(APPV717F)109Ili Apoetm1Unc/Apoetm1Unc mice (J:127846)
• plaques are observed in the the outer molecular layer of the dentate gyrus and the stratum oriens and radiatum of the hippocampus (J:127846)
• mice exhibit fibrillar plaques in the outer molecular layer of the dentate gurys (J:127846)
• 20% of mice exposed to traumatic brain injury (TBI) at 9 to 10 months of age exhibit amyloid plaques by 12 to 13 months of age while mice not exposed to TBI do not exhibit plaques until 15 months of age (J:133058)
• mice exhibit decreased plaque formation and severity following TBI compared to in similarly treated Tg(APPV717F)109Ili Tg(GFAP-APOE_i4)#Hol Apoetm1Unc/Apoetm1Unc mice (J:133058)

homeostasis/metabolism
amyloid beta deposits ( J:127846 , J:133058 )
• by 15 to 18 months, 31% of mice exhibit plaques in the hippocampus (J:127846)
• the amount of amyloid deposited is less than in Tg(APPV717F)109Ili Tg(GFAP-APOE_i4)#Hol Apoetm1Unc/Apoetm1Unc and much less than in Tg(APPV717F)109Ili Apoetm1Unc/Apoetm1Unc mice (J:127846)
• plaques are observed in the the outer molecular layer of the dentate gyrus and the stratum oriens and radiatum of the hippocampus (J:127846)
• mice exhibit fibrillar plaques in the outer molecular layer of the dentate gurys (J:127846)
• 20% of mice exposed to traumatic brain injury (TBI) at 9 to 10 months of age exhibit amyloid plaques by 12 to 13 months of age while mice not exposed to TBI do not exhibit plaques until 15 months of age (J:133058)
• mice exhibit decreased plaque formation and severity following TBI compared to in similarly treated Tg(APPV717F)109Ili Tg(GFAP-APOE_i4)#Hol Apoetm1Unc/Apoetm1Unc mice (J:133058)




Genotype
MGI:3784390
cx4
Allelic
Composition		 Apoetm1Unc/Apoetm1Unc
Tg(Eno2-APP*751)10Cord/0
Tg(GFAP-APOE_i3)37Hol/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoetm1Unc mutation (33 available); any Apoe mutation (158 available)
Tg(Eno2-APP*751)10Cord mutation (0 available)
Tg(GFAP-APOE_i3)37Hol mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased cerebral infarct size ( J:133156 )
• compared to in Tg(Eno2-APP*751)10Cord Apoetm1Unc/Apoetm1Unc mice

nervous system
decreased cerebral infarct size ( J:133156 )
• compared to in Tg(Eno2-APP*751)10Cord Apoetm1Unc/Apoetm1Unc mice
gliosis ( J:133156 )
• mice exhibit less severe microgliosis following medial cerebral artery occlusion compared to Tg(Eno2-APP*751)10Cord Apoetm1Unc/Apoetm1Unc mice




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory