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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(CSF2)2Ygy
transgene insertion 2, Yong-guang Yang
MGI:3057263
Summary 4 genotypes


Genotype
MGI:3620464
cx1
Allelic
Composition		 Tg(CSF2)2Ygy/0
Tg(IL3)1Ygy/0
Tg(KITLG)3Ygy/0
Genetic
Background		 C.Cg-Tg(CSF2)2Ygy Tg(IL3)1Ygy Tg(KITLG)3Ygy
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(CSF2)2Ygy mutation (2 available)
Tg(IL3)1Ygy mutation (2 available)
Tg(KITLG)3Ygy mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal response to transplant ( J:107052 )
• low levels of porcine chimerism are detected in the blood of recipent mice at 1 week, but all detectable chimerism in the blood is lost by 2 weeks;at 19-22 weeks after transplant, no chimerism is detected in the spleen or bone marrow
decreased susceptibility to graft versus host disease ( J:107052 )
• conditioned mice were injected with splenocytes, or PBMC and BMC from sensitized porcine donors, no recipients showed detectable GVHD




Genotype
MGI:3620239
cx2
Allelic
Composition		 Prkdcscid/Prkdcscid
Tg(CSF2)2Ygy/0
Tg(IL3)1Ygy/0
Genetic
Background		 CB17.Cg-Prkdcscid Tg(CSF2)2Ygy Tg(IL3)1Ygy
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkdcscid mutation (178 available); any Prkdc mutation (417 available)
Tg(CSF2)2Ygy mutation (2 available)
Tg(IL3)1Ygy mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal response to transplant ( J:94302 )
• engraftment of porcine bone marrow cells after bone marrow transplant into irradiated transgenic SCID mice is achieved and porcine hematopoesis is maintained at 7 weeks post-transplant with less efficiency than in mice also expressing the KITLG transgene




Genotype
MGI:3620237
cx3
Allelic
Composition		 Prkdcscid/Prkdcscid
Tg(CSF2)2Ygy/0
Tg(IL3)1Ygy/0
Tg(KITLG)3Ygy/0
Genetic
Background		 CB17.Cg-Prkdcscid Tg(CSF2)2Ygy Tg(IL3)1Ygy Tg(KITLG)3Ygy
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkdcscid mutation (178 available); any Prkdc mutation (417 available)
Tg(CSF2)2Ygy mutation (2 available)
Tg(IL3)1Ygy mutation (2 available)
Tg(KITLG)3Ygy mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal response to transplant ( J:94302 , J:106416 )
• at 1 week after transplant of bone marrow cells or PBMC from swine donors in irradiated transgenic SCID recipient mice, the percentage of porcine cells in the WBC in medronate-liposome treated (for depletion of macrophages) recipients is 10x greater than in PBS treated controls (J:94302)
• chimerism in medronate-liposome treated mice at 8 weeks post-transplant is 60% in the marrow compared to less than 30% in PBS treated controls (J:94302)
• engraftment of porcine bone marrow cells after bone marrow transplant into irradiated transgenic SCID mice is achieved and porcine hematopoesis is maintained at 7 weeks post-transplant compared to non transgenic littermates which lose porcine chimerism completely (J:106416)




Genotype
MGI:3620462
cx4
Allelic
Composition		 Prkdcscid/Prkdcscid
Tg(CSF2)2Ygy/0
Tg(IL3)1Ygy/0
Tg(KITLG)3Ygy/0
Genetic
Background		 NOD.Cg-Prkdcscid Tg(CSF2)2Ygy Tg(IL3)1Ygy Tg(KITLG)3Ygy
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkdcscid mutation (178 available); any Prkdc mutation (417 available)
Tg(CSF2)2Ygy mutation (2 available)
Tg(IL3)1Ygy mutation (2 available)
Tg(KITLG)3Ygy mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal response to transplant ( J:107052 )
• blood of NOD-SCID mouse recipients remains chimeric for porcine hematopoietic cells throughout the length of the experiment (6 weeks):
decreased susceptibility to graft versus host disease ( J:107052 )
• conditioned mice were injected with splenocytes, or PBMC and BMC from sensitized porcine donors, no recipients showed detectable GVHD




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory