All Phenotypes Nhlh2<tm1Thbr> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Nhlh2^tm1Thbr
targeted mutation 1, Thomas Braun
MGI:3057284

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nhlh2^tm1Thbr/Nhlh2^tm1Thbr	involves: 129S4/SvJae	MGI:3057322
cn2	Nhlh2^tm1Thbr/Nhlh2^tm1Thbr Tg(Pomc-EGFP)1Low/0	involves: 129S4/SvJae * C57BL/6J	MGI:5524044
cx3	Nhlh1^tm1Thbr/Nhlh1^tm1Thbr Nhlh2^tm1Thbr/Nhlh2^tm1Thbr	involves: 129S4/SvJae	MGI:3057323

Allelic Composition	Nhlh2^tm1Thbr/Nhlh2^tm1Thbr
Genetic Background	involves: 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nhlh2^tm1Thbr mutation (0 available); any Nhlh2 mutation (13 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

small ovary ( J:93303 )

small testis ( J:93303 )

growth/size/body

increased susceptibility to age related obesity ( J:93303 )

• adult onset obesity is seen in both males and females

renal/urinary system

small penis ( J:93303 )

reproductive system

small ovary ( J:93303 )

small testis ( J:93303 )

small penis ( J:93303 )

small uterus ( J:93303 )

nervous system

abnormal neuron morphology ( J:93303 )

• in adults, a 30% to 50% reduction in gonadotropin releasing hormone-positive neurons and a reduction in the projecting axons of these neurons in the median eminence and arcuate nucleus is seen

• this reduction is most pronounced in the preoptic region

Allelic Composition	Nhlh2^tm1Thbr/Nhlh2^tm1Thbr Tg(Pomc-EGFP)1Low/0
Genetic Background	involves: 129S4/SvJae * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nhlh2^tm1Thbr mutation (0 available); any Nhlh2 mutation (13 available)
Tg(Pomc-EGFP)1Low mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

decreased neuron number ( J:199640 )

• Pomc+ neurons at 15 to 21 weeks in the medial preoptic area and posterior hypothalamus

increased neuron number ( J:199640 )

• Pomc+ neurons in female mice at 3 and 6 weeks in the medial preoptic area, posterior hypothalamus and arcuate nuclei of the hypothalamus with ectopic neurons in the medial mammillary nucleus

• however, the numbers decline after 9 weeks with the onset of puberty

ectopic neuron ( J:199640 )

• ectopic Pomc+ neurons in female mice at 3 and 6 weeks in the medial mammillary nucleus

Allelic Composition	Nhlh1^tm1Thbr/Nhlh1^tm1Thbr Nhlh2^tm1Thbr/Nhlh2^tm1Thbr
Genetic Background	involves: 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nhlh1^tm1Thbr mutation (0 available); any Nhlh1 mutation (17 available)
Nhlh2^tm1Thbr mutation (0 available); any Nhlh2 mutation (13 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal neuron morphology ( J:93303 )

• at E14.5, 16.5 and E18.5 a 30%, 35%, and 73% reduction, respectively, in gonadotropin releasing hormone-positive neurons is seen, however initial proliferation of these neurons is normal

• an almost complete absence of the projecting axons of these neurons in the median eminence is also seen

decreased neuron number ( J:93303 )

• at E14.5, 16.5 and E18.5 a 30%, 35%, and 73% reduction, respectively, in gonadotropin releasing hormone-positive neurons is seen, however initial proliferation of these neurons is normal

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