Phenotypes associated with this allele

• Allele Symbol: Trp53^tm1Adv
• Allele Name: targeted mutation 1, Annemieke de Vries
• Allele ID: MGI:3057305
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Trp53^tm1Adv/Trp53^tm1Adv	involves: 129S4/SvJae * C57BL/6	MGI:3511913
ht2	Trp53^tm1Adv/Trp53^+	involves: 129S4/SvJae * C57BL/6	MGI:3511915
cx3	Mdm4^tm1Glo/Mdm4^tm1Glo Trp53^tm1Adv/Trp53^tm1Adv	involves: 129S4/SvJae	MGI:3850684
cx4	Mdm2^tm1Glo/Mdm2^tm1Glo Trp53^tm1Adv/Trp53^tm1Adv	involves: 129S7/SvEvBrd	MGI:3850687

Genotype
MGI:3511913

hm1

• Allelic Composition: Trp53^tm1Adv/Trp53^tm1Adv
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased skin tumor incidence ( J:93328 )

• the incidence of UV-induced skin tumors including papillomas and squamous cell carcinomas is increased and the latency of skin tumor development is decreased

increased skin papilloma incidence ( J:93328 )

cellular

decreased cellular sensitivity to ultraviolet irradiation ( J:93328 )

• following UV exposure apoptosis in primary MEFs from mutants is decreased compared to wild-type MEFs

integument

increased skin tumor incidence ( J:93328 )

• the incidence of UV-induced skin tumors including papillomas and squamous cell carcinomas is increased and the latency of skin tumor development is decreased

increased skin papilloma incidence ( J:93328 )

Genotype
MGI:3511915

ht2

• Allelic Composition: Trp53^tm1Adv/Trp53⁺
• Genetic Background: involves: 129S4/SvJae * C57BL/6

neoplasm

increased skin tumor incidence ( J:93328 )

• the incidence of UV-induced skin tumors including papillomas and squamous cell carcinomas is increased and the latency of skin tumor development is decreased compared to wildtype but not as much as in homozygotes

increased skin papilloma incidence ( J:93328 )

cellular

decreased cellular sensitivity to ultraviolet irradiation ( J:93328 )

• following UV exposure apoptosis in primary MEFs from mutants is decreased compared to wild-type MEFs but increased compared to homozygous mutant MEFs

integument

increased skin tumor incidence ( J:93328 )

• the incidence of UV-induced skin tumors including papillomas and squamous cell carcinomas is increased and the latency of skin tumor development is decreased compared to wildtype but not as much as in homozygotes

increased skin papilloma incidence ( J:93328 )

Genotype
MGI:3850684

cx3

• Allelic Composition: Mdm4^tm1Glo/Mdm4^tm1Glo; Trp53^tm1Adv/Trp53^tm1Adv
• Genetic Background: involves: 129S4/SvJae

mortality/aging

preweaning lethality, complete penetrance ( J:93838 )

• no mice are present at 3 weeks of age

embryo

abnormal embryo development ( J:93838 )

• embryos are abnormal at E9.5

embryonic growth retardation ( J:93838 )

• at E9.5

growth/size/body

embryonic growth retardation ( J:93838 )

• at E9.5

Genotype
MGI:3850687

cx4

• Allelic Composition: Mdm2^tm1Glo/Mdm2^tm1Glo; Trp53^tm1Adv/Trp53^tm1Adv
• Genetic Background: involves: 129S7/SvEvBrd

mortality/aging

embryonic lethality between somite formation and embryo turning, complete penetrance ( J:93838 )

• no embryos are found at E8.5