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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Fhittm1Tko
targeted mutation 1, MM Taketo
MGI:3057316
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Fhittm1Tko/Fhittm1Tko involves: 129X1/SvJ MGI:3511831
ht2
 		Fhittm1Tko/Fhit+ involves: 129X1/SvJ MGI:3511832


Genotype
MGI:3511831
hm1
Allelic
Composition		 Fhittm1Tko/Fhittm1Tko
Genetic
Background		 involves: 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fhittm1Tko mutation (0 available); any Fhit mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased hepatocellular carcinoma incidence ( J:93269 )
• occurred in 2 out of 26 homozygous mice over 12 months of age
increased lymphoma incidence ( J:93269 )
• occurred in 3 out of 26 homozygous mice over 12 months of age
increased B cell derived lymphoma incidence ( J:93269 )
• in mutants older than 12 months increased incidence of B cell lymphomas (6 out of 26) and lymphocyte infiltrations (2 out of 26) are seen
increased papilloma incidence ( J:93269 )
• forestomach papillomas occurred in 6 out of 26 homozygous mice over 12 months of age

digestive/alimentary system
abnormal small intestine morphology ( J:93269 )
• small intestinal lesions including polyps (7 out of 26), fused villi (3 out of 26) and swollen crypts (1 out of 26) are seen

liver/biliary system
increased hepatocellular carcinoma incidence ( J:93269 )
• occurred in 2 out of 26 homozygous mice over 12 months of age




Genotype
MGI:3511832
ht2
Allelic
Composition		 Fhittm1Tko/Fhit+
Genetic
Background		 involves: 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fhittm1Tko mutation (0 available); any Fhit mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased lymphoma incidence ( J:93269 )
• occurred in 2 out of 90 heterozygous mice over 12 months of age
increased B cell derived lymphoma incidence ( J:93269 )
• in mutants older than 12 months increased incidence of B cell lymphomas (16 out of 90) and lymphocyte infiltrations (5 out of 90) are seen
increased papilloma incidence ( J:93269 )
• forestomach papillomas occurred in 22 out of 90 heterozygous mice over 12 months of age

digestive/alimentary system
abnormal small intestine morphology ( J:93269 )
• small intestinal lesions including polyps (6 out of 90), fused villi (5 out of 90) and swollen crypts (8 out of 90) are seen




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory