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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gata3tm1Jfz
targeted mutation 1, Jinfang Zhu
MGI:3487291
Summary 9 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Gata3tm1Jfz/Gata3tm1Jfz involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3511353
cn2
 		Gata3tm1Jfz/Gata3tm1Jfz
Zfp157Gt(XC356)Byg/Zfp157Gt(XC356)Byg
Tg(LGB-cre)74Acl/0 		involves: 129 * C57BL/6 * CBA MGI:5427847
cn3
 		Bhlhe22tm3.1(cre)Meg/Bhlhe22+
Gata3tm1Jfz/Gata3tm2Gsv
Gt(ROSA)26Sortm1(CAG-Mafb,-tdTomato)Good/Gt(ROSA)26Sor+ 		involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ MGI:5581690
cn4
 		Bhlhe22tm3.1(cre)Meg/Bhlhe22+
Gata3tm1Jfz/Gata3tm1Jfz 		involves: 129S1/Sv * 129X1/SvJ MGI:5581689
cn5
 		Gata3tm1Jfz/Gata3tm1Jfz
Tg(Tnfrsf4-cre)1Nik/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3511355
cn6
 		Gata3tm1Jfz/Gata3tm1Jfz
Tg(LGB-cre)74Acl/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA MGI:5427849
cn7
 		Gata3tm1Jfz/Gata3tm1Jfz
Tg(Cd4-cre)1Cwi/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2 MGI:3511354
cn8
 		Gata3tm1Jfz/Gata3tm1Jfz
Tg(Fev-cre)1Esd/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL MGI:4837221
cn9
 		Gata3tm1Jfz/Gata3tm1Jfz
Rag2tm1Fwa/Rag2tm1Fwa
Tg(Cd4-cre)1Cwi/0
Tg(Tcra5CC7,Tcrb5CC7)IWep/0 		involves: 129S/SvEv * C57BL/6 * DBA/2 MGI:3817641


Genotype
MGI:3511353
hm1
Allelic
Composition		 Gata3tm1Jfz/Gata3tm1Jfz
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata3tm1Jfz mutation (0 available); any Gata3 mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:93538 )
• homozygous mice display no phenotypic abnormalities




Genotype
MGI:5427847
cn2
Allelic
Composition		 Gata3tm1Jfz/Gata3tm1Jfz
Zfp157Gt(XC356)Byg/Zfp157Gt(XC356)Byg
Tg(LGB-cre)74Acl/0
Genetic
Background		 involves: 129 * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata3tm1Jfz mutation (0 available); any Gata3 mutation (32 available)
Tg(LGB-cre)74Acl mutation (2 available)
Zfp157Gt(XC356)Byg mutation (0 available); any Zfp157 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:184505 )
N
• rescue of the lactation failure seen in mutant mice wild-type for Zfp157

integument
abnormal mammary gland luminal epithelium morphology ( J:184505 )
• mild epithelial dysplasia in all ducts and alveoli with an increase in the number of binucleate cells and cells of variable sizes

endocrine/exocrine glands
abnormal mammary gland luminal epithelium morphology ( J:184505 )
• mild epithelial dysplasia in all ducts and alveoli with an increase in the number of binucleate cells and cells of variable sizes




Genotype
MGI:5581690
cn3
Allelic
Composition		 Bhlhe22tm3.1(cre)Meg/Bhlhe22+
Gata3tm1Jfz/Gata3tm2Gsv
Gt(ROSA)26Sortm1(CAG-Mafb,-tdTomato)Good/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bhlhe22tm3.1(cre)Meg mutation (0 available); any Bhlhe22 mutation (12 available)
Gata3tm1Jfz mutation (0 available); any Gata3 mutation (32 available)
Gata3tm2Gsv mutation (0 available); any Gata3 mutation (32 available)
Gt(ROSA)26Sortm1(CAG-Mafb,-tdTomato)Good mutation (0 available); any Gt(ROSA)26Sor mutation (993 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal inner hair cell synaptic ribbon morphology ( J:207904 )
• partial rescue of ribbon loss observed Mafbtm1.1Good/Mafbtm1Jeng Tg(Neurog1-cre)1Jejo mice
abnormal cochlear ganglion morphology ( J:207904 )
• partial rescue of synaptic defects observed Mafbtm1.1Good/Mafbtm1Jeng Tg(Neurog1-cre)1Jejo mice

hearing/vestibular/ear
abnormal inner hair cell synaptic ribbon morphology ( J:207904 )
• partial rescue of ribbon loss observed Mafbtm1.1Good/Mafbtm1Jeng Tg(Neurog1-cre)1Jejo mice




Genotype
MGI:5581689
cn4
Allelic
Composition		 Bhlhe22tm3.1(cre)Meg/Bhlhe22+
Gata3tm1Jfz/Gata3tm1Jfz
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bhlhe22tm3.1(cre)Meg mutation (0 available); any Bhlhe22 mutation (12 available)
Gata3tm1Jfz mutation (0 available); any Gata3 mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal cochlear ganglion morphology ( J:207904 )
• cochlear synaptic loss is more severe than in Mafbtm1.1Good/Mafbtm1Jeng Tg(Neurog1-cre)1Jejo mice




Genotype
MGI:3511355
cn5
Allelic
Composition		 Gata3tm1Jfz/Gata3tm1Jfz
Tg(Tnfrsf4-cre)1Nik/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata3tm1Jfz mutation (0 available); any Gata3 mutation (32 available)
Tg(Tnfrsf4-cre)1Nik mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
increased T-helper 1 cell number ( J:93538 )
• increased numbers of IFN-gamma producing cells in response to Nippostrongylus brasiliensis infection
decreased T-helper 2 cell number ( J:93538 )
• decreased numbers of Il-4 producing cells in response to Nippostrongylus brasiliensis infection
decreased IgE level ( J:93538 )
• very little IgE in the serum in response to Nippostrongylus brasiliensis infection

immune system
increased T-helper 1 cell number ( J:93538 )
• increased numbers of IFN-gamma producing cells in response to Nippostrongylus brasiliensis infection
decreased T-helper 2 cell number ( J:93538 )
• decreased numbers of Il-4 producing cells in response to Nippostrongylus brasiliensis infection
decreased IgE level ( J:93538 )
• very little IgE in the serum in response to Nippostrongylus brasiliensis infection
increased susceptibility to parasitic infection ( J:93538 )
• failed to expel worms after Nippostrongylus brasiliensis infection




Genotype
MGI:5427849
cn6
Allelic
Composition		 Gata3tm1Jfz/Gata3tm1Jfz
Tg(LGB-cre)74Acl/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata3tm1Jfz mutation (0 available); any Gata3 mutation (32 available)
Tg(LGB-cre)74Acl mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument
abnormal mammary gland growth during lactation ( J:184505 )
• very few expanded alveoli are seen
lactation failure ( J:184505 )
• pups show little milk in their stomachs and are severely dehydrated

endocrine/exocrine glands
abnormal mammary gland growth during lactation ( J:184505 )
• very few expanded alveoli are seen
lactation failure ( J:184505 )
• pups show little milk in their stomachs and are severely dehydrated




Genotype
MGI:3511354
cn7
Allelic
Composition		 Gata3tm1Jfz/Gata3tm1Jfz
Tg(Cd4-cre)1Cwi/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata3tm1Jfz mutation (0 available); any Gata3 mutation (32 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T cell differentiation ( J:141145 )
• when mutant bone marrow cells are transferred to mice lacking surface expression of MHC I, the single positive T cell population in the thymus is composed of small numbers of CD8+ T cells instead of large numbers of CD4+ T cells
abnormal CD4-positive, alpha beta T cell morphology ( J:93538 )
• substantially decreased numbers of CD4+ single positive cells but normal numbers of CD8+ single positive cells
• CD4+ cells found in the lymph nodes had an activated or memory-like phenotype
decreased CD4-positive, alpha-beta T cell number ( J:141145 )
• the number of TCRhi CD4 thymocytes is much smaller (0.2 x 106) than in their wild-type counterparts (10.9 x 106)
• the number of CD4 T cells found in the periphery is very small and all have a memory phenotype suggesting they are descendents of an even smaller progenitor pool
• CD4 T cells are virtually absent in the spleen of 1 week old mice, giving further evidence that CD4 T cell population in adults results from expansion of a small progenitor pool
decreased interleukin-13 secretion ( J:172134 )
• in stimulated T cells

hematopoietic system
abnormal T cell differentiation ( J:141145 )
• when mutant bone marrow cells are transferred to mice lacking surface expression of MHC I, the single positive T cell population in the thymus is composed of small numbers of CD8+ T cells instead of large numbers of CD4+ T cells
abnormal CD4-positive, alpha beta T cell morphology ( J:93538 )
• substantially decreased numbers of CD4+ single positive cells but normal numbers of CD8+ single positive cells
• CD4+ cells found in the lymph nodes had an activated or memory-like phenotype
decreased CD4-positive, alpha-beta T cell number ( J:141145 )
• the number of TCRhi CD4 thymocytes is much smaller (0.2 x 106) than in their wild-type counterparts (10.9 x 106)
• the number of CD4 T cells found in the periphery is very small and all have a memory phenotype suggesting they are descendents of an even smaller progenitor pool
• CD4 T cells are virtually absent in the spleen of 1 week old mice, giving further evidence that CD4 T cell population in adults results from expansion of a small progenitor pool




Genotype
MGI:4837221
cn8
Allelic
Composition		 Gata3tm1Jfz/Gata3tm1Jfz
Tg(Fev-cre)1Esd/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata3tm1Jfz mutation (0 available); any Gata3 mutation (32 available)
Tg(Fev-cre)1Esd mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal Raphe nucleus morphology ( J:165266 )
• decrease in the number of Tph immunoreactive cells in the dorsal Raphe nucleus

homeostasis/metabolism
decreased serotonin level ( J:165266 )
• in the dorsal Raphe nucleus




Genotype
MGI:3817641
cn9
Allelic
Composition		 Gata3tm1Jfz/Gata3tm1Jfz
Rag2tm1Fwa/Rag2tm1Fwa
Tg(Cd4-cre)1Cwi/0
Tg(Tcra5CC7,Tcrb5CC7)IWep/0
Genetic
Background		 involves: 129S/SvEv * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata3tm1Jfz mutation (0 available); any Gata3 mutation (32 available)
Rag2tm1Fwa mutation (45 available); any Rag2 mutation (119 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
Tg(Tcra5CC7,Tcrb5CC7)IWep mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T cell differentiation ( J:141145 )
• T cells expressing the transgenic MHC class II-restricted TCR show diversion from the CD4+ lineage to the CD8+ lineage

hematopoietic system
abnormal T cell differentiation ( J:141145 )
• T cells expressing the transgenic MHC class II-restricted TCR show diversion from the CD4+ lineage to the CD8+ lineage




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory