All Phenotypes Sncb<tm1.1Sud> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Sncb^tm1.1Sud
targeted mutation 1.1, Thomas C Sudhof
MGI:3487297

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sncb^tm1.1Sud/Sncb^tm1.1Sud	involves: 129S1/Sv * 129X1/SvJ	MGI:3511216
cx2	Dnajc5^tm1Sud/Dnajc5^tm1Sud Snca^tm1Sud/Snca^tm1Sud Sncb^tm1.1Sud/Sncb^tm1.1Sud	involves: 129P2/OlaHsd * 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ	MGI:3768080
cx3	Snca^tm1Sud/Snca^tm1Sud Sncb^tm1.1Sud/Sncb^tm1.1Sud	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ	MGI:3511218

Allelic Composition	Sncb^tm1.1Sud/Sncb^tm1.1Sud
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sncb^tm1.1Sud mutation (1 available); any Sncb mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:93544 )

• mice were viable and fertile

• no age dependent phenotypes developed over more than 1.5 years

Allelic Composition	Dnajc5^tm1Sud/Dnajc5^tm1Sud Snca^tm1Sud/Snca^tm1Sud Sncb^tm1.1Sud/Sncb^tm1.1Sud
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnajc5^tm1Sud mutation (2 available); any Dnajc5 mutation (24 available)
Snca^tm1Sud mutation (1 available); any Snca mutation (36 available)
Sncb^tm1.1Sud mutation (1 available); any Sncb mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:115193 )

• mice die suddenly within a few days after weaning (average lifespan ~23.8 days); even if mutants are left with the mother, survival is <30 days

growth/size/body

decreased body weight ( J:115193 )

• at P8, triple mutants weigh less than their littermates and at P20 are ~50% of wild-type littermates

nervous system

neurodegeneration ( J:115193 )

• degenerating neurons are found in brain and spinal cord of mutants

• mice show accelerated degeneration relative to Dnajc5-null animals at 10 days of age

Allelic Composition	Snca^tm1Sud/Snca^tm1Sud Sncb^tm1.1Sud/Sncb^tm1.1Sud
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Snca^tm1Sud mutation (1 available); any Snca mutation (36 available)
Sncb^tm1.1Sud mutation (1 available); any Sncb mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal striatum morphology ( J:93544 )

• dopamine levels decreased by 18% in the striatum but metabolic levels are normal

homeostasis/metabolism

decreased dopamine level ( J:93544 )

• dopamine levels decreased by 18% in the striatum but metabolic levels are normal

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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