All Phenotypes Pax3<tm1Mrc> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Pax3^tm1Mrc
targeted mutation 1, Mario R Capecchi
MGI:3487369

Summary

8 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pax3^tm1Mrc/Pax3^tm1Mrc	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3510827
cn2	Myf6^tm1(cre)Mrc/Myf6⁺ Pax3^tm1Mrc/Pax3^tm1Mrc Trp53^tm1Brn/Trp53⁺	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	MGI:3844657
cn3	Myf6^tm1(cre)Mrc/Myf6⁺ Pax3^tm1Mrc/Pax3^tm1Mrc Trp53^tm1Brn/Trp53^tm1Brn	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	MGI:3844658
cn4	Pax3^tm1Mrc/Pax3⁺ Tg(CMV-cre)1Cgn/?	involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6	MGI:3510830
cn5	Pax3^tm1Mrc/Pax3⁺ Pax7^tm1(cre)Mrc/Pax7⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3510831
cn6	Myf6^tm1(cre)Mrc/Myf6⁺ Pax3^tm1Mrc/Pax3⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	MGI:3844656
cn7	Foxo1^tm1Mrc/Foxo1^tm1Mrc Myf6^tm1(cre)Mrc/Myf6⁺ Pax3^tm1Mrc/Pax3^tm1Mrc	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	MGI:3844661
cn8	Cdkn2a^tm4Rdp/Cdkn2a^tm4Rdp Myf6^tm1(cre)Mrc/Myf6⁺ Pax3^tm1Mrc/Pax3^tm1Mrc	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	MGI:3844659

Allelic Composition	Pax3^tm1Mrc/Pax3^tm1Mrc
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax3^tm1Mrc mutation (1 available); any Pax3 mutation (50 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:93444 )

• homozygotes are normal and fertile

Allelic Composition	Myf6^tm1(cre)Mrc/Myf6⁺ Pax3^tm1Mrc/Pax3^tm1Mrc Trp53^tm1Brn/Trp53⁺
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myf6^tm1(cre)Mrc mutation (0 available); any Myf6 mutation (19 available)
Pax3^tm1Mrc mutation (1 available); any Pax3 mutation (50 available)
Trp53^tm1Brn mutation (18 available); any Trp53 mutation (240 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased rhabdomyosarcoma incidence ( J:93444 )

• 1 in 12 mice develop an rhabdomyosarcoma by day 202

muscle

increased rhabdomyosarcoma incidence ( J:93444 )

• 1 in 12 mice develop an rhabdomyosarcoma by day 202

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
alveolar rhabdomyosarcoma		DOID:4051	OMIM:268220	J:93444

Allelic Composition	Myf6^tm1(cre)Mrc/Myf6⁺ Pax3^tm1Mrc/Pax3^tm1Mrc Trp53^tm1Brn/Trp53^tm1Brn
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased rhabdomyosarcoma incidence ( J:93444 )

• 2 in 5 mice develop an rhabdomyosarcoma by day 75 to 91

muscle

increased rhabdomyosarcoma incidence ( J:93444 )

• 2 in 5 mice develop an rhabdomyosarcoma by day 75 to 91

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
alveolar rhabdomyosarcoma		DOID:4051	OMIM:268220	J:93444

Allelic Composition	Pax3^tm1Mrc/Pax3⁺ Tg(CMV-cre)1Cgn/?
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax3^tm1Mrc mutation (1 available); any Pax3 mutation (50 available)
Tg(CMV-cre)1Cgn mutation (6 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

absent frontal bone ( J:93443 )

• the frontal bone is absent

absent interparietal bone ( J:93443 )

absent parietal bone ( J:93443 )

absent premaxilla ( J:93443 )

maxilla hypoplasia ( J:93443 )

abnormal nasal bone morphology ( J:93443 )

• dysgenesis of the nasal bone is seen

cranioschisis ( J:93443 )

muscle

thin diaphragm muscle ( J:93443 )

hypaxial muscle hypoplasia ( J:93443 )

skeleton

absent frontal bone ( J:93443 )

• the frontal bone is absent

absent interparietal bone ( J:93443 )

absent parietal bone ( J:93443 )

absent premaxilla ( J:93443 )

maxilla hypoplasia ( J:93443 )

abnormal nasal bone morphology ( J:93443 )

• dysgenesis of the nasal bone is seen

cranioschisis ( J:93443 )

abnormal sternum morphology ( J:93443 )

• midline fusion of the sternum is incomplete

rib fusion ( J:93443 )

• multiple rib fusions are seen

vertebral fusion ( J:93443 )

• multiple vertebral fusions are seen

vision/eye

optic placode degeneration ( J:93443 )

• the optic placode is present at E8.75 but completely degenerated by E12.5

anophthalmia ( J:93443 )

nervous system

midbrain hyperplasia ( J:93443 )

• disorganized, ectopic midbrain hyperplasia of neuroectodermal precursors is seen by E12.5

abnormal forebrain morphology ( J:93443 )

forebrain hypoplasia ( J:93443 )

• forebrain hypoplasia is visible at E9.75

abnormal cerebral cortex morphology ( J:93443 )

• the cortex is disorganized

absent olfactory bulb ( J:93443 )

• olfactory lobe agenesis is seen

exencephaly ( J:93443 )

small dorsal root ganglion ( J:93443 )

• the dorsal root ganglia is hyperplastic

growth/size/body

abnormal nasal bone morphology ( J:93443 )

• dysgenesis of the nasal bone is seen

omphalocele ( J:93443 )

respiratory system

abnormal nasal bone morphology ( J:93443 )

• dysgenesis of the nasal bone is seen

Allelic Composition	Pax3^tm1Mrc/Pax3⁺ Pax7^tm1(cre)Mrc/Pax7⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax3^tm1Mrc mutation (1 available); any Pax3 mutation (50 available)
Pax7^tm1(cre)Mrc mutation (2 available); any Pax7 mutation (38 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:93443 )

• because of breathing difficulties few mutants survive beyond 3.5 months of age

neoplasm

neoplasm ( J:93443 )

N	• no alveolar rhabdomyosarcomas are detected

craniofacial

abnormal premaxilla morphology ( J:93443 )

• agenesis of the rostral premaxilla is seen

maxilla hypoplasia ( J:93443 )

lacrimal bone hypoplasia ( J:93443 )

• hypoplasia of the lacrimal bone is seen

abnormal nose morphology ( J:93443 )

• a narrowed nose is seen

turbinate hypoplasia ( J:93443 )

• the nasal turbinates are underdeveloped

growth/size/body

abnormal nose morphology ( J:93443 )

• a narrowed nose is seen

turbinate hypoplasia ( J:93443 )

• the nasal turbinates are underdeveloped

decreased body weight ( J:93443 )

• at 3 weeks of age mutants weigh less than one-third of wild-type littermates

postnatal growth retardation ( J:93443 )

• severe growth retardation is seen by 3 weeks of age

muscle

decreased skeletal muscle fiber diameter ( J:93443 )

• myofiber diameter is reduced

decreased skeletal muscle mass ( J:93443 )

• muscle mass is reduced

decreased satellite cell number ( J:93443 )

• the number of satellite cells is reduced

increased skeletal muscle fiber density ( J:93443 )

• myofiber density is increased

muscle hypoplasia ( J:93443 )

respiratory system

abnormal nose morphology ( J:93443 )

• a narrowed nose is seen

turbinate hypoplasia ( J:93443 )

• the nasal turbinates are underdeveloped

skeleton

abnormal premaxilla morphology ( J:93443 )

• agenesis of the rostral premaxilla is seen

maxilla hypoplasia ( J:93443 )

lacrimal bone hypoplasia ( J:93443 )

• hypoplasia of the lacrimal bone is seen

turbinate hypoplasia ( J:93443 )

• the nasal turbinates are underdeveloped

Allelic Composition	Myf6^tm1(cre)Mrc/Myf6⁺ Pax3^tm1Mrc/Pax3⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased rhabdomyosarcoma incidence ( J:93444 )

• 1 in 228 mice develop an rhabdomyosarcoma that arises from the pectoralis major muscle by day 383

muscle

increased rhabdomyosarcoma incidence ( J:93444 )

• 1 in 228 mice develop an rhabdomyosarcoma that arises from the pectoralis major muscle by day 383

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
alveolar rhabdomyosarcoma		DOID:4051	OMIM:268220	J:93444

Allelic Composition	Foxo1^tm1Mrc/Foxo1^tm1Mrc Myf6^tm1(cre)Mrc/Myf6⁺ Pax3^tm1Mrc/Pax3^tm1Mrc
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxo1^tm1Mrc mutation (0 available); any Foxo1 mutation (32 available)
Myf6^tm1(cre)Mrc mutation (0 available); any Myf6 mutation (19 available)
Pax3^tm1Mrc mutation (1 available); any Pax3 mutation (50 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

neoplasm ( J:93444 )

N	• mice do not exhibit accelerated tumorigenesis

Allelic Composition	Cdkn2a^tm4Rdp/Cdkn2a^tm4Rdp Myf6^tm1(cre)Mrc/Myf6⁺ Pax3^tm1Mrc/Pax3^tm1Mrc
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2a^tm4Rdp mutation (0 available); any Cdkn2a mutation (67 available)
Myf6^tm1(cre)Mrc mutation (0 available); any Myf6 mutation (19 available)
Pax3^tm1Mrc mutation (1 available); any Pax3 mutation (50 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased rhabdomyosarcoma incidence ( J:93444 )

• 4 in 14 mice develop an rhabdomyosarcoma by day 56 to 89

muscle

increased rhabdomyosarcoma incidence ( J:93444 )

• 4 in 14 mice develop an rhabdomyosarcoma by day 56 to 89

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
alveolar rhabdomyosarcoma		DOID:4051	OMIM:268220	J:93444

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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