Phenotypes associated with this allele

• Allele Symbol: Snca^tm1Sud
• Allele Name: targeted mutation 1, Thomas C Sudhof
• Allele ID: MGI:3487373
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Snca^tm1Sud/Snca^tm1Sud	involves: 129P2/OlaHsd * C57BL/6	MGI:3510542
cx2	Dnajc5^tm1Sud/Dnajc5^tm1Sud Snca^tm1Sud/Snca^tm1Sud Sncb^tm1.1Sud/Sncb^tm1.1Sud	involves: 129P2/OlaHsd * 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ	MGI:3768080
cx3	Snca^tm1Sud/Snca^tm1Sud Sncb^tm1.1Sud/Sncb^tm1.1Sud	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ	MGI:3511218
cx4	Dnajc5^tm1Sud/Dnajc5^tm1Sud Snca^tm1Sud/Snca^tm1Sud	involves: 129P2/OlaHsd * 129S6/SvEvTac	MGI:3768084

Genotype
MGI:3510542

hm1

• Allelic Composition: Snca^tm1Sud/Snca^tm1Sud
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal dopaminergic neuron morphology ( J:93686 )

• no signs of Parkinsonism in mice up to ages beyond 1 year

• resistant to the lethal effects of MPTP and less paralysis at the highest doses

• at lower MPTP doses, dopamine losses about half what is seen in controls

• effects of metamphetamine were opposite, 47% decrease in dopamine as compared to a 25% decrease in controls

Genotype
MGI:3768080

cx2

• Allelic Composition: Dnajc5^tm1Sud/Dnajc5^tm1Sud; Snca^tm1Sud/Snca^tm1Sud; Sncb^tm1.1Sud/Sncb^tm1.1Sud
• Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ

mortality/aging

premature death ( J:115193 )

• mice die suddenly within a few days after weaning (average lifespan ~23.8 days); even if mutants are left with the mother, survival is <30 days

growth/size/body

decreased body weight ( J:115193 )

• at P8, triple mutants weigh less than their littermates and at P20 are ~50% of wild-type littermates

nervous system

neurodegeneration ( J:115193 )

• degenerating neurons are found in brain and spinal cord of mutants

• mice show accelerated degeneration relative to Dnajc5-null animals at 10 days of age

Genotype
MGI:3511218

cx3

• Allelic Composition: Snca^tm1Sud/Snca^tm1Sud; Sncb^tm1.1Sud/Sncb^tm1.1Sud
• Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

nervous system

abnormal striatum morphology ( J:93544 )

• dopamine levels decreased by 18% in the striatum but metabolic levels are normal

homeostasis/metabolism

decreased dopamine level ( J:93544 )

• dopamine levels decreased by 18% in the striatum but metabolic levels are normal

Genotype
MGI:3768084

cx4

• Allelic Composition: Dnajc5^tm1Sud/Dnajc5^tm1Sud; Snca^tm1Sud/Snca^tm1Sud
• Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

mortality/aging

premature death ( J:115193 )

• double mutants display intermediate lifespan with average length between that of Snca,Dnajc5 double-null mice and Dnajc5-null mice