Phenotypes associated with this allele

• Allele Symbol: Socs7^tm1Wsa
• Allele Name: targeted mutation 1, Warren S Alexander
• Allele ID: MGI:3487375
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Socs7^tm1Wsa/Socs7^tm1Wsa	involves: C57BL/6	MGI:3510251

Genotype
MGI:3510251

hm1

• Allelic Composition: Socs7^tm1Wsa/Socs7^tm1Wsa
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Phenotype of Socs7^tm1Wsa/Socs7^tm1Wsa mice

mortality/aging

premature death ( J:93449 )

• around 50% of homozygotes die between 3-15 weeks of age

behavior/neurological

lethargy ( J:93449 )

• lethargy is seen with hydroencephaly

aphagia ( J:93449 )

• mutants fail to eat

decreased locomotor activity ( J:93449 )

• mutants exhibit reduced activity

cardiovascular system

intracranial hemorrhage ( J:93449 )

• bleeding on the surface of the brain is seen in some mutants with hydroencephaly

endocrine/exocrine glands

enlarged pancreatic islets ( J:93449 )

• the islets are larger than normal and show more intense insulin staining

abnormal subcommissural organ morphology ( J:93449 )

• the subcommissural organ is disorganized in the presence or absence of hydroencephaly

growth/size/body

decreased body weight ( J:93449 )

• homozygotes weigh 7-10% less than wild-type littermates from 4 to 14 weeks of age

megacephaly ( J:93449 )

nervous system

intracranial hemorrhage ( J:93449 )

• bleeding on the surface of the brain is seen in some mutants with hydroencephaly

abnormal subcommissural organ morphology ( J:93449 )

• the subcommissural organ is disorganized in the presence or absence of hydroencephaly

hydrocephaly ( J:93449 )

• enlargement of the fluid-filled lateral ventricles and in severely affected mutants the fourth ventricle is seen

• many areas of the brain are compressed and displaced caudally

abnormal hippocampus morphology ( J:93449 )

• transition from the retrosplenial cortex to the hippocampus is disrupted in mutants with hydroencephaly

abnormal cerebral cortex morphology ( J:93449 )

• the cerebral cortex is thinner than normal with less discrete layers in mutants with hydroencephaly

craniofacial

abnormal cranial suture morphology ( J:93449 )

• mutants with overt hydrocephalus ehxibit a failure of calvarial bone suture closure

skeleton

abnormal cranial suture morphology ( J:93449 )

• mutants with overt hydrocephalus ehxibit a failure of calvarial bone suture closure