Analysis Tools|
Allele Symbol Allele Name Allele ID |
Pax7tm1(cre)Mrc targeted mutation 1, Mario R Capecchi MGI:3497712 |
||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Summary |
13 genotypes
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• no calcification occurs in the fibrous capsule surrounding the muzzle vibrissae
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• at E15.5, rhythmic activity in the pre-Botzinger complex is preserved
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• earlier tumor onset, from 32 to 65 days of age
• bortezomib treated mice have better survival
|
|
• earlier tumor onset, from 32 to 65 days of age
• bortezomib treated mice have better survival
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• reduction in myogenic precursor marker Pax7 peptide level and 50% reduction in Pax7+ myogenic precursor cells in E16.5 embryos
• significantly reduced levels of committed myoblast markers MyoD and myogenin peptide levels and 60% reduction in MyoD+ myoblasts in E16.5 embryos
• 7x increased MyHC-slow peptide levels in E16.5 embryos
|
| N |
• normal apoptosis in E16.5 embryos
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice are viable and do not show any apparent developmental abnormalities and have regular numbers of Pax7+ muscle stem cells (satellite cells)
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• the increased body weight seen in homozygous 2310065F04Riktm1.1Boet mice is normalized
|
| N |
• mice show complete abrogation of the increased number of Pax7+ muscle stem cells (satellite cells) and of the increased EdU-labeled quiescent muscle stem cells, the increased tibialis anterior muscle weight, and the muscle hypertrophy and increased myonuclei numbers in fibers that are seen in homozygous 2310065F04Riktm1.1Boet mice
• mice do not show the general myofiber hypertrophy that is seen in homozygous 2310065F04Riktm1.1Boet mice 4 weeks after cardiotoxin-induced muscle damage
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• no live embryos are recovered
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• live embryos at E18.5 but no live progeny
|
|
• severe craniofacial deformation
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• no pups are born but they can be recovered at E15.5
|
|
• Pax7+ lineage cells are mostly absent except in the proximity to cartilaginous regions of the developing maxilla and nasal turbinates
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• because of breathing difficulties few mutants survive beyond 3.5 months of age
|
|
• agenesis of the rostral premaxilla is seen
|
|
• hypoplasia of the lacrimal bone is seen
|
|
• a narrowed nose is seen
|
|
• the nasal turbinates are underdeveloped
|
|
• a narrowed nose is seen
|
|
• the nasal turbinates are underdeveloped
|
|
• at 3 weeks of age mutants weigh less than one-third of wild-type littermates
|
|
• severe growth retardation is seen by 3 weeks of age
|
|
• myofiber diameter is reduced
|
|
• muscle mass is reduced
|
|
• the number of satellite cells is reduced
|
|
• myofiber density is increased
|
|
• a narrowed nose is seen
|
|
• the nasal turbinates are underdeveloped
|
|
• agenesis of the rostral premaxilla is seen
|
|
• hypoplasia of the lacrimal bone is seen
|
|
• the nasal turbinates are underdeveloped
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• 9 of 30 double heterozygous mice become ataxic starting around 88-100 days of age
|
|
• all ataxic mice have rapidly growing tumors in the cerebellum
• high nuclear to cytoplasm ratio in tumor cells
• tumors invade the subarachnoid space
• evidence of leptomeningeal metastasis
|
|
• all ataxic mice have rapidly growing tumors in the cerebellum
• high nuclear to cytoplasm ratio in tumor cells
• tumors invade the subarachnoid space
• evidence of leptomeningeal metastasis
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 11/12/2024 MGI 6.24 |
|
|
|
||
