Analysis Tools|
Allele Symbol Allele Name Allele ID |
Pax7tm1(cre)Mrc targeted mutation 1, Mario R Capecchi MGI:3497712 |
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| Summary |
14 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• no calcification occurs in the fibrous capsule surrounding the muzzle vibrissae
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• at E15.5, rhythmic activity in the pre-Botzinger complex is preserved
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• earlier tumor onset, from 32 to 65 days of age
• bortezomib treated mice have better survival
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• earlier tumor onset, from 32 to 65 days of age
• bortezomib treated mice have better survival
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• reduction in myogenic precursor marker Pax7 peptide level and 50% reduction in Pax7+ myogenic precursor cells in E16.5 embryos
• significantly reduced levels of committed myoblast markers MyoD and myogenin peptide levels and 60% reduction in MyoD+ myoblasts in E16.5 embryos
• 7x increased MyHC-slow peptide levels in E16.5 embryos
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| N |
• normal apoptosis in E16.5 embryos
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• although born at the expected Mendelian ratio, all homozygous pups die within a few hours after birth; no live pups older than 1 day are recovered
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• pulmonary alveoli fail to open in newborn pups
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• at P1, TEM analysis showed severe disruption of the sarcomeric structures in both the diaphragm and hindlimb muscles
• however, some residual sarcomeres are still present in skeletal muscles
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• at P1, pups show defective sarcomeres in striated muscles; skeletal muscles of P1 pups show an obvious increase in protein levels of non-muscle myosin IIs (MYH9 and MYH10)
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice are viable and do not show any apparent developmental abnormalities and have regular numbers of Pax7+ muscle stem cells (satellite cells)
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• the increased body weight seen in homozygous 2310065F04Riktm1.1Boet mice is normalized
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| N |
• mice show complete abrogation of the increased number of Pax7+ muscle stem cells (satellite cells) and of the increased EdU-labeled quiescent muscle stem cells, the increased tibialis anterior muscle weight, and the muscle hypertrophy and increased myonuclei numbers in fibers that are seen in homozygous 2310065F04Riktm1.1Boet mice
• mice do not show the general myofiber hypertrophy that is seen in homozygous 2310065F04Riktm1.1Boet mice 4 weeks after cardiotoxin-induced muscle damage
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• no live embryos are recovered
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• live embryos at E18.5 but no live progeny
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• severe craniofacial deformation
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• no pups are born but they can be recovered at E15.5
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• Pax7+ lineage cells are mostly absent except in the proximity to cartilaginous regions of the developing maxilla and nasal turbinates
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• because of breathing difficulties few mutants survive beyond 3.5 months of age
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• agenesis of the rostral premaxilla is seen
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• hypoplasia of the lacrimal bone is seen
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• a narrowed nose is seen
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• the nasal turbinates are underdeveloped
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• a narrowed nose is seen
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• the nasal turbinates are underdeveloped
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• at 3 weeks of age mutants weigh less than one-third of wild-type littermates
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• severe growth retardation is seen by 3 weeks of age
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• myofiber diameter is reduced
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• muscle mass is reduced
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• the number of satellite cells is reduced
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• myofiber density is increased
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• a narrowed nose is seen
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• the nasal turbinates are underdeveloped
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• agenesis of the rostral premaxilla is seen
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• hypoplasia of the lacrimal bone is seen
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• the nasal turbinates are underdeveloped
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 9 of 30 double heterozygous mice become ataxic starting around 88-100 days of age
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• all ataxic mice have rapidly growing tumors in the cerebellum
• high nuclear to cytoplasm ratio in tumor cells
• tumors invade the subarachnoid space
• evidence of leptomeningeal metastasis
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• all ataxic mice have rapidly growing tumors in the cerebellum
• high nuclear to cytoplasm ratio in tumor cells
• tumors invade the subarachnoid space
• evidence of leptomeningeal metastasis
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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