Phenotypes associated with this allele

• Allele Symbol: Ddit4^tm1Fein
• Allele Name: targeted mutation 1, Elena Feinstein
• Allele ID: MGI:3497720
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ddit4^tm1Fein/Ddit4^tm1Fein	involves: 129S5/SvEvBrd * C57BL/6	MGI:3510242

Genotype
MGI:3510242

hm1

• Allelic Composition: Ddit4^tm1Fein/Ddit4^tm1Fein
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal retina vasculature morphology ( J:93450 )

• vascular cell death and neo-vascularization following exposure of pups from P7 to P12 to hyperoxic conditions are significantly reduced compared to wild-type mice

decreased retina apoptosis ( J:93450 )

• apoptosis of the inner nuclear layer following exposure of pups from P7 to P12 to hyperoxic conditions is significantly reduced compared to wild-type mice

• in normoxic conditions no differences are detected in the retinas of mutants compared to wild-type littermates

nervous system

hypermyelination ( J:202688 )

• in the peripheral nervous system at P10, P30 and P90

cardiovascular system

abnormal retina vasculature morphology ( J:93450 )

• vascular cell death and neo-vascularization following exposure of pups from P7 to P12 to hyperoxic conditions are significantly reduced compared to wild-type mice

cellular

decreased retina apoptosis ( J:93450 )

• apoptosis of the inner nuclear layer following exposure of pups from P7 to P12 to hyperoxic conditions is significantly reduced compared to wild-type mice

• in normoxic conditions no differences are detected in the retinas of mutants compared to wild-type littermates