Phenotypes associated with this allele

• Allele Symbol: Parp1^tm2Zqw
• Allele Name: targeted mutation 2, Zhao-Qi Wang
• Allele ID: MGI:3497740
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Parp1^tm2Zqw/Parp1^tm2Zqw	either: (involves: 129P2/OlaHsd * 129/Sv) or (involves: 129P2/OlaHsd * C57BL/6)	MGI:3510100

Genotype
MGI:3510100

hm1

• Allelic Composition: Parp1^tm2Zqw/Parp1^tm2Zqw
• Genetic Background: either: (involves: 129P2/OlaHsd * 129/Sv) or (involves: 129P2/OlaHsd * C57BL/6)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal macrophage physiology ( J:93479 )

• secreted about 50% less NO than wild-type after 24 hour treatment with LPS

decreased circulating interleukin-1 beta level ( J:93479 )

• 2 hours after LPS treatment, induction of IL-1beta was significantly compromised in sera

decreased circulating tumor necrosis factor level ( J:93479 )

• 2 hours after LPS treatment or 1 hour after splanchnic artery occlusion shock, production of TNF-alpha was lower in sera

abnormal inflammatory response ( J:93479 )

decreased inflammatory response ( J:93479 )

• resistant to tissue damage caused by intestinal and renal ischemia-reperfusion

decreased susceptibility to endotoxin shock ( J:93479 )

• mutants were more resistant to LPS-induced septic shock, with approximately 40% surviving whereas all wild-types died

homeostasis/metabolism

decreased circulating interleukin-1 beta level ( J:93479 )

• 2 hours after LPS treatment, induction of IL-1beta was significantly compromised in sera

decreased circulating tumor necrosis factor level ( J:93479 )

• 2 hours after LPS treatment or 1 hour after splanchnic artery occlusion shock, production of TNF-alpha was lower in sera

hematopoietic system

abnormal macrophage physiology ( J:93479 )

• secreted about 50% less NO than wild-type after 24 hour treatment with LPS