Phenotypes associated with this allele

• Allele Symbol: Plod3^tm1Soin
• Allele Name: targeted mutation 1, Raija Soininen
• Allele ID: MGI:3497741
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Plod3^tm1Soin/Plod3^tm1Soin	involves: 129	MGI:3510437

Genotype
MGI:3510437

hm1

• Allelic Composition: Plod3^tm1Soin/Plod3^tm1Soin
• Genetic Background: involves: 129

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:93434 )

• homozygous embryos die around E9.5-E10.5

cellular

abnormal intracellular organelle morphology ( J:93434 )

• at E9.5 in cells from homozygous embryos the basement membranes are fragmented, the endoplasmic reticulum is dilated, and the Golgi complexes and lysosomes are enlarged

embryo

abnormal preimplantation embryo development ( J:93434 )

• cellular density is decreased in homozygous embryos at E9.5

embryonic growth retardation ( J:93434 )

• homozygous embryos are developmentally retarded and fragile after E8.5

decreased embryo size ( J:93434 )

• at E8.5 homozygous embryos are about 60% of the size of wild-type littermates

growth/size/body

embryonic growth retardation ( J:93434 )

• homozygous embryos are developmentally retarded and fragile after E8.5

decreased embryo size ( J:93434 )

• at E8.5 homozygous embryos are about 60% of the size of wild-type littermates