All Phenotypes Irs2<tm2Tka> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Irs2^tm2Tka
targeted mutation 2, Tetsuo Noda
MGI:3497742

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Irs1^tm2Tka/Irs1^tm2Tka Irs2^tm2Tka/Irs2^tm2Tka Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA	MGI:3805348
cn2	Irs2^tm2Tka/Irs2^tm2Tka Tg(Ins2-cre)25Mgn/0	involves: 129S4/SvJae * C57BL/6	MGI:3510986
cn3	Irs2^tm2Tka/Irs2^tm2Tka Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺	involves: 129S4/SvJae * C57BL/6 * DBA	MGI:3805349

Allelic Composition	Irs1^tm2Tka/Irs1^tm2Tka Irs2^tm2Tka/Irs2^tm2Tka Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irs1^tm2Tka mutation (0 available); any Irs1 mutation (52 available)
Irs2^tm2Tka mutation (0 available); any Irs2 mutation (37 available)
Speer6-ps1^{Tg(Alb-cre)21Mgn} mutation (6 available); any Speer6-ps1 mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

insulin resistance ( J:137846 )

• under fasting and refeeding conditions

immune system

increased susceptibility to autoimmune diabetes ( J:137846 )

• mice develop diabetes

• however, over-expression of a dominant negative Foxo1 by adenoviral transfection improves diabetes

Allelic Composition	Irs2^tm2Tka/Irs2^tm2Tka Tg(Ins2-cre)25Mgn/0
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irs2^tm2Tka mutation (0 available); any Irs2 mutation (37 available)
Tg(Ins2-cre)25Mgn mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

adipose tissue

increased epididymal fat pad weight ( J:93416 )

• the mass of the epididymal fat pad is increased at 12 weeks of age

endocrine/exocrine glands

decreased pancreatic beta cell mass ( J:93416 )

• beta cell mass is significantly reduced with or without caloric restriction at 8 and 12 weeks of age

• however at 10 days of age beta cell mass is not reduced

growth/size/body

increased body weight ( J:93416 )

• body weights are significantly greater than controls by 5 weeks of age

obese ( J:93416 )

• on a regular or high fat diet mutants become obese, however pair fed mutants do not become obese

homeostasis/metabolism

increased circulating glucose level ( J:93416 )

• on a high fat diet but not regular chow fasting glucose levels are significantly elevated

increased circulating leptin level ( J:93416 )

• fasting serum leptin levels are significantly increased

increased circulating cholesterol level ( J:93416 )

increased circulating triglyceride level ( J:93416 )

impaired glucose tolerance ( J:93416 )

insulin resistance ( J:93416 )

• insulin resistance is seen in mutants without caloric restriction or on a high fat diet

decreased response to leptin ( J:93416 )

• suppression of food intake by exogenous leptin is decreased, suggesting leptin resistance

Allelic Composition	Irs2^tm2Tka/Irs2^tm2Tka Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺
Genetic Background	involves: 129S4/SvJae * C57BL/6 * DBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irs2^tm2Tka mutation (0 available); any Irs2 mutation (37 available)
Speer6-ps1^{Tg(Alb-cre)21Mgn} mutation (6 available); any Speer6-ps1 mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:137846 )

N	• mice exhibit normal hepatic triglyceride content, serum aspartate aminotransferase and alanine aminotransferase indicating a lack of hepatic injury

increased circulating insulin level ( J:137846 )

• mice exhibit higher serum insulin levels 24 hours after fasting and 30 and 60 minutes after the start of refeeding unlike wild-type mice

insulin resistance ( J:137846 )

• mice exhibit insulin resistance under fasting conditions

• however, mice do not exhibit insulin resistance under refeeding conditions

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