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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Mybtm1Epr
targeted mutation 1, E Premkumar Reddy
MGI:3497746
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Mybtm1Epr/Mybtm1Epr
Tg(Lck-cre)548Jxm/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA MGI:3511178
cn2
Mybtm1Epr/Mybtm1Epr
Tg(Cd4-cre)1Cwi/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2 MGI:3511179


Genotype
MGI:3511178
cn1
Allelic
Composition
Mybtm1Epr/Mybtm1Epr
Tg(Lck-cre)548Jxm/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mybtm1Epr mutation (1 available); any Myb mutation (53 available)
Tg(Lck-cre)548Jxm mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• cellularity of the thymus is reduced to 11% of controls
• thymocytes accumulate at the DN3 stage
• reduced numbers of cells at the DN4 stage
• double positive cell population reduced to 62% of normal

immune system
• cellularity of the thymus is reduced to 11% of controls
• thymocytes accumulate at the DN3 stage
• reduced numbers of cells at the DN4 stage
• double positive cell population reduced to 62% of normal

endocrine/exocrine glands
• cellularity of the thymus is reduced to 11% of controls




Genotype
MGI:3511179
cn2
Allelic
Composition
Mybtm1Epr/Mybtm1Epr
Tg(Cd4-cre)1Cwi/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mybtm1Epr mutation (1 available); any Myb mutation (53 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• cellularity of the thymus is reduced by 17%
• double positive cell proportion is similar to controls but absolute numbers are reduced by 17%
• CD4+ cell numbers are reduced
• CD8+ cell numbers are increased

immune system
• cellularity of the thymus is reduced by 17%
• double positive cell proportion is similar to controls but absolute numbers are reduced by 17%
• CD4+ cell numbers are reduced
• CD8+ cell numbers are increased

endocrine/exocrine glands
• cellularity of the thymus is reduced by 17%





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory