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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Bcl6btm1Tto
targeted mutation 1, Takeshi Tokuhisa
MGI:3497910
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Bcl6btm1Tto/Bcl6btm1Tto involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3510549


Genotype
MGI:3510549
hm1
Allelic
Composition		 Bcl6btm1Tto/Bcl6btm1Tto
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl6btm1Tto mutation (0 available); any Bcl6b mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal CD4-positive, alpha beta T cell morphology ( J:93656 )
• cell proliferation is reduced both in the thymus and in the spleen
abnormal CD8-positive, alpha beta T cell morphology ( J:93656 )
• proliferation reduced in the thymus; however memory B cell proliferation is normal

immune system
abnormal CD4-positive, alpha beta T cell morphology ( J:93656 )
• cell proliferation is reduced both in the thymus and in the spleen
abnormal CD8-positive, alpha beta T cell morphology ( J:93656 )
• proliferation reduced in the thymus; however memory B cell proliferation is normal




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory