About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(AZIP/F)1Vsn
transgene insertion 1, Charles Vinson
MGI:3497939
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Bglap/Bglap2tm1Kry/Bglap/Bglap2tm1Kry
Tg(AZIP/F)1Vsn/0
involves: 129S7/SvEvBrd * FVB/N MGI:3837377
cx2
Bglap/Bglap2tm1Kry/Bglap/Bglap2tm1Kry
Tg(AZIP/F)1Vsn/0
involves: 129S7/SvEvBrd * FVB/N MGI:3837378
tg3
Tg(AZIP/F)1Vsn/0 FVB-Tg(AZIP/F)1Vsn/J MGI:3837369
tg4
Tg(AZIP/F)1Vsn/0 involves: FVB/N MGI:3510460


Genotype
MGI:3837377
cx1
Allelic
Composition
Bglap/Bglap2tm1Kry/Bglap/Bglap2tm1Kry
Tg(AZIP/F)1Vsn/0
Genetic
Background
involves: 129S7/SvEvBrd * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bglap/Bglap2tm1Kry mutation (1 available); any Bglap mutation (13 available)
Tg(AZIP/F)1Vsn mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• mice exhibit elevated serum insulin levels compared to in wild-type mice that are half as much as in Tg(AZIP/F)1Vsn mice




Genotype
MGI:3837378
cx2
Allelic
Composition
Bglap/Bglap2tm1Kry/Bglap/Bglap2tm1Kry
Tg(AZIP/F)1Vsn/0
Genetic
Background
involves: 129S7/SvEvBrd * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bglap/Bglap2tm1Kry mutation (1 available); any Bglap2 mutation (9 available)
Tg(AZIP/F)1Vsn mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• mice exhibit elevated serum insulin levels compared to in wild-type mice that are half as much as in Tg(AZIP/F)1Vsn mice




Genotype
MGI:3837369
tg3
Allelic
Composition
Tg(AZIP/F)1Vsn/0
Genetic
Background
FVB-Tg(AZIP/F)1Vsn/J
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• insulin content in the pancreata is increased compared to in wild-type mice
• at birth and 2 weeks of age, mice exhibit increased serum insulin levels compared to in wild-type mice
• however, mice treated with isoproterenol exhibit lowered serum levels of insulin

endocrine/exocrine glands
• beta-cell proliferation is increased compared to in wild-type mice
• beta-cell proliferation, mass and area are increased compared to in wild-type mice
• insulin content in the pancreata is increased compared to in wild-type mice

growth/size/body
• at 2 weeks of age
• at 2 weeks of age

cellular
• beta-cell proliferation is increased compared to in wild-type mice




Genotype
MGI:3510460
tg4
Allelic
Composition
Tg(AZIP/F)1Vsn/0
Genetic
Background
involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• transgenic mice are more sensitive to death after anesthesia than wild-type mice
• survival after weaning is reduced
• normal numbers of transgenic pups are born however by weaning the percentage of transgenic pups is decreased to 30% (from 50%)
• almost no pups from litters produced by hemizygous females survive until weaning

adipose tissue
• transgenic mice have decreased brown fat at birth which is primarily inactive and resembles white adipose tissue
• transgenic mice have essentially no white fat as a result of a failure to generate white adipose tissue cells

behavior/neurological
• transgenic mice drink 4 times more than wild-type mice

endocrine/exocrine glands
• the islet cells are hyperplastic and hypertrophic with a large increase in the number of beta cells

growth/size/body
• when fasted adult transgenic mice lose weight faster than non-transgenic mice
• transgenic mice are heavier than wild-type mice at 8-11 weeks of age as a result of an increase in the weights of multiple organs including the liver, heart, kidneys, and spleen
• transgenic mice have increased abdominal girth compared to wild-type mice
• transgenic mice grow slower than wild-type mice before weaning, weighing 50% and 80% of wild-type weight at 1 and 3 weeks of age, respectively
• liver weight is increased 2.1-fold accounting for less than 50% of the total body weight increase in transgenic mice

homeostasis/metabolism
• free active leptin levels are about 5% of wild-type mice
• serum glucose is increased about 3-fold compared to wild-type mice
• elevated serum glucose is first detected 3 weeks after birth and reaches diabetic levels by 4 weeks
• when fasted serum glucose levels drop to a much greater extent than in non-transgenic mice
• serum insulin levels are increased 58- and 442-fold in male and female transgenic mice
• insulin levels are already elevated 30-fold by 1 week after birth
• when fasted serum insulin levels drop to a much greater extent than in non-transgenic mice
• circulating free fatty acid are increased 1.5- to 2.5 fold compared to wild-type mice however no signs of ketosis are detected
• when fasted circulating free fatty acid levels drop rather than rise as in wild-type mice
• serum triglyceride levels are elevated 3- to 5-fold
• the livers of transgenic mice contain 6.8-fold higher triglyceride levels compared to wild-type mice
• transgenic mice are more sensitive to death after anesthesia than wild-type mice

liver/biliary system
• liver weight is increased 2.1-fold accounting for less than 50% of the total body weight increase in transgenic mice
• the livers of transgenic mice contain 6.8-fold higher triglyceride levels compared to wild-type mice
• the liver is pale with lipid accumulation in a zone 3/centrilobular pattern

renal/urinary system
• transgenic mice have a significantly higher urine output than normal

reproductive system
• females have reduced fertility and litter size with almost no pups surviving until weaning
• male fertility is decreased but litters that are produced are of normal size

respiratory system
• lipid loaded phagocytic cells are seen in the lungs of some transgenic mice





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
12/10/2024
MGI 6.24
The Jackson Laboratory