Analysis Tools
nervous system
|
• prolonged transition between G1 to S of neural stem cells in the ventricular zone
• cortical progenitor neurons differentiate precociously leading to an increased number of deep layer neurons at E15.5 and E18.5
• At E15.5, increase in proliferation of cells outside the ventricular zone (postmitotic region)
|
|
• reduced size is apparent from E11.5 onwards
|
|
• approximately 50% reduction in hippocampal primodium
|
|
• smaller lateral ventricles at E15.5 and E18.5
|
|
• thickening of the neocortex
|
|
• at E12.5, the ventricular surface was about 30% smaller along the mediolateral axis than in wild-type
• reduced ventricular surface along the rostrocaudal axis at E15.5 and E18.5
|
cellular
|
• prolonged transition between G1 to S of neural stem cells in the ventricular zone
• cortical progenitor neurons differentiate precociously leading to an increased number of deep layer neurons at E15.5 and E18.5
• At E15.5, increase in proliferation of cells outside the ventricular zone (postmitotic region)
|
