Phenotypes associated with this allele

• Allele Symbol: Cnr1^tm1Ojm
• Allele Name: targeted mutation 1, Olivier J Manzoni
• Allele ID: MGI:3505551
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cnr1^tm1Ojm/Cnr1^tm1Ojm	involves: 129P2/OlaHsd * C57BL/6	MGI:3510689

Genotype
MGI:3510689

hm1

• Allelic Composition: Cnr1^tm1Ojm/Cnr1^tm1Ojm
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

decreased total body fat amount ( J:93697 )

• reduced fat content when fed ad libitum a standard or obesity-prone regiment

behavior/neurological

abnormal food intake ( J:93697 )

• male mutants ate less food (about 10% fewer calories) than wild-type over 24 hours

• transient hyperphagia in response to a high fat diet was not seen in mutants

growth/size/body

decreased body weight ( J:93697 )

• at 20 weeks of age, male mutants weighed 24% less than wild-types when maintained ad libitum on standard chow

decreased susceptibility to diet-induced obesity ( J:93697 )

• males fed an obesity-prone regiment gained less weight than wild-types on the standard or obesity-prone diet and did not become obese

homeostasis/metabolism

decreased susceptibility to diet-induced obesity ( J:93697 )

• males fed an obesity-prone regiment gained less weight than wild-types on the standard or obesity-prone diet and did not become obese

decreased circulating insulin level ( J:93697 )

• plasma insulin levels were low in males fed standard chow and remained low in males fed the obesity-prone diet

decreased circulating leptin level ( J:93697 )

• reduced plasma leptin levels in male mutants maintained ad libitum on standard chow

increased insulin sensitivity ( J:93697 )

• increased insulin sensitivity on obesity-prone diet compared to wild-type on the same diet, however blood glucose did increase

increased response to leptin ( J:93697 , J:93698 )

• leptin injection induced a higher weight loss (4.7% in wild-type vs. 7.5% in mutants) in mutant males than in wild-type (J:93697)

• leptin injection induced greater decrease in food intake (J:93698)

nervous system

abnormal excitatory postsynaptic potential ( J:93698 )

• absence of agonist-induced field excitatory postsynaptic potential inhibition (98% of baseline in mutants compared to 29% in wild-type)

absent long-term depression ( J:93698 )

• tetanic stimulation (at 13-Hz) of prelimbic cortical afferents did not induce a long term depression