Phenotypes associated with this allele

• Allele Symbol: Mmp19^tm1Amp
• Allele Name: targeted mutation 1, Alberto M Pendas
• Allele ID: MGI:3505589
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mmp19^tm1Amp/Mmp19^tm1Amp	Not Specified	MGI:3505708

Genotype
MGI:3505708

hm1

• Allelic Composition: Mmp19^tm1Amp/Mmp19^tm1Amp
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

increased susceptibility to diet-induced obesity ( J:90802 )

• after 30 weeks on a high-fat diet, a pronounced weight gain was observed in both females and males due to an overall increase in both subcutaneous and gonadal fat pad deposits

homeostasis/metabolism

increased susceptibility to diet-induced obesity ( J:90802 )

• after 30 weeks on a high-fat diet, a pronounced weight gain was observed in both females and males due to an overall increase in both subcutaneous and gonadal fat pad deposits

decreased incidence of tumors by chemical induction ( J:90802 )

• intradermal injection of a single dose of the chemical carcinogen MCA resulted in fewer fibrosarcomas with a longer latency period than in wild-type

adipose tissue

increased fat cell size ( J:90802 )

• after 30 weeks on a high-fat diet, surfaces of subcutaneous, gonadal and skin adipocytes were bigger than wild-type except for the gonadal fat pad from male mutants and the number of adipocytes per surface unit was lower

abnormal fat pad morphology ( J:90802 )

• after 30 weeks on a high-fat diet, weight of subcutaneous fat pad from the posterior iliac crest deposits was higher than in wild-type

increased gonadal fat pad weight ( J:90802 )

• after 30 weeks on a high-fat diet, weight of gonadal fat pad deposits was significantly higher in females but not males than in wild-type

neoplasm

decreased incidence of tumors by chemical induction ( J:90802 )

• intradermal injection of a single dose of the chemical carcinogen MCA resulted in fewer fibrosarcomas with a longer latency period than in wild-type