Phenotypes associated with this allele

• Allele Symbol: Tg(CETP)5203Tall
• Allele Name: transgene insertion 5203, Alan Tall
• Allele ID: MGI:3505595
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Apoc1^tm1Lmh/Apoc1^tm1Lmh Tg(CETP)5203Tall/0	involves: 129P2/OlaHsd * C57BL/6 * CBA/J	MGI:3697301
cx2	Apobec1^tm1Chan/Apobec1^tm1Chan Tg(CETP)5203Tall/0	involves: 129S4/SvJae * C57BL/6J * CBA/J	MGI:3850550
tg3	Tg(CETP)5203Tall/0	involves: C57BL/6 * CBA/J	MGI:3697302
tg4	Tg(CETP)5203Tall/0	involves: C57BL/6J * CBA/J	MGI:3835380

Genotype
MGI:3697301

cx1

• Allelic Composition: Apoc1^tm1Lmh/Apoc1^tm1Lmh; Tg(CETP)5203Tall/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal lipid level ( J:117482 )

• hepatic level increase is attenuated by transgene expression (by 58.2%) compared to controls

• hepatic cholesteryl ester levels are significantly higher than in wild-type or Tg(CETP)5203Tall controls

increased bile salt level ( J:117482 )

• bile acid level is increased by 19.6% compared to wild-type, Apoc1-deficient, or Tg(CETP)5303Tall mice

increased cholesterol level ( J:117482 )

• biliary cholesterol levels are increased by 87.7% compared to Tg(CETP)5203Tall mice; bile cholesterol is increased compared to Apoc1-deficient or Tg(CETP)5203Tall mice

abnormal phospholipid level ( J:117482 )

• levels are increased compared to wild-type or Tg(CETP)5203Tall mice

increased liver triglyceride level ( J:117482 )

• 302.4% increased in hepatic triglyceride levels vs wild-type or Tg(CETP)5303Tall controls

liver/biliary system

increased liver triglyceride level ( J:117482 )

• 302.4% increased in hepatic triglyceride levels vs wild-type or Tg(CETP)5303Tall controls

abnormal bile composition ( J:117482 )

• all lipids in bile are increased in concentration compared to wild-type levels; cholesterol to bile salt ratio is increased by 54.3% and phospholipids to bile salt ratio is increased 48.1% compared to Tg(CETP)5303Tall mice

Genotype
MGI:3850550

cx2

• Allelic Composition: Apobec1^tm1Chan/Apobec1^tm1Chan; Tg(CETP)5203Tall/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6J * CBA/J

homeostasis/metabolism

abnormal circulating cholesterol level ( J:48202 )

• circulating VLDL/LDL cholesterol levels are increased compared to in Tg(CETP)5203Tall mice, Apobec1^tm1Chan homozygotes, and wild-type mice

decreased circulating HDL cholesterol level ( J:48202 )

• compared to in Apobec1^tm1Chan homozygotes and wild-type mice

increased circulating cholesterol level ( J:48202 )

• after 4 and 16 weeks on a Western-type diet compared to in Tg(CETP)5203Tall mice

decreased circulating triglyceride level ( J:48202 )

• after 2 on a Western-type diet compared to in Apobec1^tm1Chan homozygotes

increased circulating triglyceride level ( J:48202 )

• mice exhibit increased serum triglyceride levels compared with wild-type mice

• after 2 on a Western-type diet, mice exhibit an increase in serum triglyceride levels compared with Tg(CETP)5203Tall mice

Genotype
MGI:3697302

tg3

• Allelic Composition: Tg(CETP)5203Tall/0
• Genetic Background: involves: C57BL/6 * CBA/J

homeostasis/metabolism

abnormal lipid level ( J:117482 )

• hepatic cholesteryl ester level is lower than in Apoc1-defcient mice

decreased cholesterol level ( J:117482 )

• biliary level is decreased compared to Apoc1-deficient mice

abnormal phospholipid level ( J:117482 )

• biliary level is decreased compared to Apoc1-deficient mice

decreased liver triglyceride level ( J:117482 )

• hepatic levels are significantly lower than in Apoc1-deficient mice

liver/biliary system

decreased liver triglyceride level ( J:117482 )

• hepatic levels are significantly lower than in Apoc1-deficient mice

Genotype
MGI:3835380

tg4

• Allelic Composition: Tg(CETP)5203Tall/0
• Genetic Background: involves: C57BL/6J * CBA/J

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:128254 )

N • despite being fed an atherogenic diet, mice exhibit no change in total cholesterol, triglyceride and HDL-cholesterol levels compared to similarly treated wild-type mice

decreased circulating HDL cholesterol level ( J:48202 )

• compared to in Apobec1^tm1Chan homozygotes and wild-type mice