Phenotypes associated with this allele

• Allele Symbol: Tg(MMTV-Cdc37)1Stp
• Allele Name: transgene insertion 1, Lilia Stepanova
• Allele ID: MGI:3505709
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Tg(MMTV-Cdc37)1Stp/0 Tg(MMTV-Myc)141-3Led/0	involves: C57BL/6 * CD-1 * DBA/2 * FVB/N	MGI:3839909
cx2	Tg(MMTV-CCND1)1Esmp/0 Tg(MMTV-Cdc37)1Stp/0	involves: C57BL/6 * DBA/2 * FVB/N	MGI:3839910
tg3	Tg(MMTV-Cdc37)1Stp/0	involves: C57BL/6 * DBA/2 * FVB/N	MGI:3839907

Genotype
MGI:3839909

cx1

• Allelic Composition: Tg(MMTV-Cdc37)1Stp/0; Tg(MMTV-Myc)141-3Led/0
• Genetic Background: involves: C57BL/6 * CD-1 * DBA/2 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased tumor incidence ( J:62465 )

♀ • 50% of female mice develop tumors by 115 days compared to the same rate at 250 days in Tg(MMTV-Myc)141-3Led mice

♀ • females exhibit increased tumors per mouse compared to in Tg(MMTV-Myc)141-3Led mice

♀ • virgin females develop a wider spectrum of fast growing tumors compared to Tg(MMTV-Myc)141-3Led virgin females

increased salivary adenocarcinoma incidence ( J:62465 )

♀ • in virgin females

increased mammary gland tumor incidence ( J:62465 )

♀ • breeding females develop mammary ductal and alveolar adenocarcinomas

increased mammary adenocarcinoma incidence ( J:62465 )

♀ • in virgin females

increased Leydig cell tumor incidence ( J:62465 )

♂ • Leydig cell tumors in males as young as 10 months

increased lymphoma incidence ( J:62465 )

♀ • in virgin females

reproductive system

increased Leydig cell number ( J:62465 )

♂ • 75% of male mice exhibit Leydig cell hyperplasia at 400 days

increased Leydig cell tumor incidence ( J:62465 )

♂ • Leydig cell tumors in males as young as 10 months

endocrine/exocrine glands

increased salivary adenocarcinoma incidence ( J:62465 )

♀ • in virgin females

increased mammary gland tumor incidence ( J:62465 )

♀ • breeding females develop mammary ductal and alveolar adenocarcinomas

increased mammary adenocarcinoma incidence ( J:62465 )

♀ • in virgin females

increased Leydig cell number ( J:62465 )

♂ • 75% of male mice exhibit Leydig cell hyperplasia at 400 days

increased Leydig cell tumor incidence ( J:62465 )

♂ • Leydig cell tumors in males as young as 10 months

integument

increased mammary gland tumor incidence ( J:62465 )

♀ • breeding females develop mammary ductal and alveolar adenocarcinomas

increased mammary adenocarcinoma incidence ( J:62465 )

♀ • in virgin females

digestive/alimentary system

increased salivary adenocarcinoma incidence ( J:62465 )

♀ • in virgin females

craniofacial

increased salivary adenocarcinoma incidence ( J:62465 )

♀ • in virgin females

growth/size/body

increased salivary adenocarcinoma incidence ( J:62465 )

♀ • in virgin females

Genotype
MGI:3839910

cx2

• Allelic Composition: Tg(MMTV-CCND1)1Esmp/0; Tg(MMTV-Cdc37)1Stp/0
• Genetic Background: involves: C57BL/6 * DBA/2 * FVB/N

neoplasm

increased mammary gland tumor incidence ( J:62465 )

♀ • in female mice as young as 13 months of age with mean age of onset of 430 days compared to 565 days in Tg(MMTV-Cdc37)1Stp mice and 450 days in Tg(MMTV-CCND1)1Tcw mice

♀ • female mice exhibit metastasis to the lungs

increased mammary adenocarcinoma incidence ( J:62465 )

♀ • female mice develop rapidly dividing single mass adenocarcinomas most of which are well-differentiated

integument

increased mammary gland tumor incidence ( J:62465 )

♀ • in female mice as young as 13 months of age with mean age of onset of 430 days compared to 565 days in Tg(MMTV-Cdc37)1Stp mice and 450 days in Tg(MMTV-CCND1)1Tcw mice

♀ • female mice exhibit metastasis to the lungs

increased mammary adenocarcinoma incidence ( J:62465 )

♀ • female mice develop rapidly dividing single mass adenocarcinomas most of which are well-differentiated

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:62465 )

♀ • in female mice as young as 13 months of age with mean age of onset of 430 days compared to 565 days in Tg(MMTV-Cdc37)1Stp mice and 450 days in Tg(MMTV-CCND1)1Tcw mice

♀ • female mice exhibit metastasis to the lungs

increased mammary adenocarcinoma incidence ( J:62465 )

♀ • female mice develop rapidly dividing single mass adenocarcinomas most of which are well-differentiated

Genotype
MGI:3839907

tg3

• Allelic Composition: Tg(MMTV-Cdc37)1Stp/0
• Genetic Background: involves: C57BL/6 * DBA/2 * FVB/N

neoplasm

increased tumor incidence ( J:62465 )

♀ • by 22 months of age, 100% of female mice develop mammary or lymphoid tumors

increased mammary adenocarcinoma incidence ( J:62465 )

♀ • 10% of female mice develop mammary ductal adenocarcinoma

increased mammary adenoacanthoma incidence ( J:62465 )

♀ • 60% of female mice develop mammary ductal adeno-squamous carinoma

increased lymphoma incidence ( J:62465 )

♀ • in 50% of female mice

endocrine/exocrine glands

abnormal mammary gland development ( J:62465 )

♂ • 60% to 70% of male mice exhibit development of the mammary ductal system by 7 months of age

♂ • during the first 6 weeks after birth, most male mice fail to exhibit regression of initial breast sprouts observed in wild-type mice

♂ • by 8 weeks, 70% of male mice have well-developed branching duct systems unlike in wild-type male mice

increased mammary adenocarcinoma incidence ( J:62465 )

♀ • 10% of female mice develop mammary ductal adenocarcinoma

increased mammary adenoacanthoma incidence ( J:62465 )

♀ • 60% of female mice develop mammary ductal adeno-squamous carinoma

integument

abnormal mammary gland development ( J:62465 )

♂ • 60% to 70% of male mice exhibit development of the mammary ductal system by 7 months of age

♂ • during the first 6 weeks after birth, most male mice fail to exhibit regression of initial breast sprouts observed in wild-type mice

♂ • by 8 weeks, 70% of male mice have well-developed branching duct systems unlike in wild-type male mice

increased mammary adenocarcinoma incidence ( J:62465 )

♀ • 10% of female mice develop mammary ductal adenocarcinoma

increased mammary adenoacanthoma incidence ( J:62465 )

♀ • 60% of female mice develop mammary ductal adeno-squamous carinoma