Analysis Tools
behavior/neurological
limb grasping
(
J:93869
)
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• at 8 to 12 weeks of age
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• at 16 weeks of age, mice exhibit poor performance on a rotarod test compared to wild-type mice
• at 26 weeks of age, mice exhibit impaired motor performance compared to wild-type mice
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• at 16 weeks of age
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nervous system
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• loss of dendritic arbor precedes loss of Purkinje cells unlike in wild-type mice
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• at 4 weeks, mice exhibit progressive loss of calbindin-28K immunoreactive Purkinje cells that is preceded by loss of dendritic arbor unlike in wild-type mice
• by 24 to 27 weeks, mice exhibit a 50% to 53% loss of Purkinje cells compared to in wild-type mice
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