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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nbntm1Md
targeted mutation 1, Martin Digweed
MGI:3505755
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Nbntm1Md/Nbntm1Zqw
Tg(Mx1-cre)1Cgn/0 		involves: 129/Sv * 129P2/OlaHsd * C57BL/6 * CBA MGI:3510438


Genotype
MGI:3510438
cn1
Allelic
Composition		 Nbntm1Md/Nbntm1Zqw
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 involves: 129/Sv * 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nbntm1Md mutation (0 available); any Nbn mutation (59 available)
Nbntm1Zqw mutation (0 available); any Nbn mutation (59 available)
Tg(Mx1-cre)1Cgn mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
chromosome breakage ( J:93598 )
• recombined lymphocytes show increased chromosomal instability and cells in which cre mediated excision occurred are preferentially lost from the bone marrow, thymus, and spleen

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
Nijmegen breakage syndrome DOID:7400 OMIM:251260
 J:93598




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory