Phenotypes associated with this allele

• Allele Symbol: Grid2^ho-15J
• Allele Name: hotfoot 15 Jackson
• Allele ID: MGI:3505770
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Grid2^ho-15J/Grid2^ho-15J	C3(Cg)-Grid2^ho-15J/GrsrJ	MGI:3574842
hm2	Grid2^ho-15J/Grid2^ho-15J	involves: C3HeB/Fe	MGI:5635067

Genotype
MGI:3574842

hm1

• Allelic Composition: Grid2^ho-15J/Grid2^ho-15J
• Genetic Background: C3(Cg)-Grid2^ho-15J/GrsrJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

ataxia ( J:94301 )

• when walking, mice exhibit a slight jolting throughout the length of the body and a wobbly gait

abnormal head movements ( J:94301 )

• lateral and vertical head movement is much milder than that presented by lurcher mutants

abnormal gait ( J:94301 )

• when walking, mice slowly raise their rear feet high into the flank while holding their rear feet more rigidly than normal, but they do not exhibit the more common walking- on- hot coals phenotype of other hotfoot mutations

abnormal sexual interaction ( J:94301 )

♂ • females breed, but males do not breed well

Genotype
MGI:5635067

hm2

• Allelic Composition: Grid2^ho-15J/Grid2^ho-15J
• Genetic Background: involves: C3HeB/Fe

behavior/neurological

ataxia ( J:220519 )

abnormal eye movement ( J:220519 )

• larger spontaneous and random eye movements

vision/eye

abnormal eye movement ( J:220519 )

• larger spontaneous and random eye movements

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
autosomal recessive spinocerebellar ataxia 18		DOID:0080042	OMIM:616204	J:220519