Analysis Tools|
Allele Symbol Allele Name Allele ID |
Ido1tm1Alm targeted mutation 1, Andrew L Mellor MGI:3505776 |
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| Summary |
6 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• tryptophan plasma levels are normal
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• males exhibit normal fertility and testis weight
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• increase in the proportion of spermatozoa exhibiting abnormal morphology, including pinhead, giant head, hairpin and kite spermatozoa
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• whereas wild-type caput epididymis exhibits a high KYN/Trp ratio indicating that it is in an immunosuppressed state, mutants have a much lower KYN/Trp ratio, indicating that the caput epididymis is in an inflammatory state
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• caudal epididymal sperm counts are nearly twice as high in mutants as in wild-type males
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• levels of some cytokines are higher in mutant caput epididymis
• significantly greater amounts of protein in caput epididymis extracts than in controls
• lysosomal autophagy is seen in mutant but not wild-type caput epididymal tissues
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• increase in the proportion of spermatozoa exhibiting abnormal morphology, including pinhead, giant head, hairpin and kite spermatozoa
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• lysosomal autophagy is seen in mutant but not wild-type caput epididymal tissues as indicated by an increase in multilamellar/multivesicular bodies
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• decrease in leukocyte count in caudal epididymal fluid
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• lysosomal autophagy is seen in mutant but not wild-type caput epididymal tissues as indicated by an increase in multilamellar/multivesicular bodies
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• significantly greater amounts of protein in caput epididymis extracts than in controls due to decreased protein degradation
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• levels of some cytokines are higher in mutant caput epididymis
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• decrease in leukocyte count in caudal epididymal fluid
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• levels of some cytokines are higher in mutant caput epididymis
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• whereas wild-type caput epididymis exhibits a high KYN/Trp ratio indicating that it is in an immunosuppressed state, mutants have a much lower KYN/Trp ratio, indicating that the caput epididymis is in an inflammatory state
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• CD19+ dendritic cells fail to express IFNalpha following B7 ligation
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• after CTLA4-Ig treatment, no spleen cells show expression of IFNalpha
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• peritoneal macrophages show disrupted mitochondrial morphology
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• peritoneal macrophages show reduced numbers of mitochondria
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• marker analysis indicates increased mitophagy in peritoneal macrophages
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• peritoneal macrophage mitochondria show a deficit only in complex I activity
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• peritoneal macrophages show disrupted mitochondrial morphology and reduced numbers of mitochondria
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• primary mouse peritoneal macrophages exhibit reduced cellular NAD+ amounts and suppressed oxygen consumption while having increased glycolysis, thus disrupting macrophage respiration
• supplementation of peritoneal macrophages with kynurenine restores NAD+ levels and normalizes oxygen consumption and extracellular acidification rate
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• marker analysis indicates increased mitophagy in peritoneal macrophages
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• mice stimulated with LPS show a decrease in plasma concentration of kynurenine and the downstream kynurenine metabolites 3-hydroxykynureinie (3-HK), 3-hydroxyanthranilic acid (3-HANA) and QA compared to wild-type mice
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• mice stimulated with LPS show a decrease in plasma concentration of kynurenine and the downstream kynurenine metabolites 3-hydroxykynureinie (3-HK), 3-hydroxyanthranilic acid (3-HANA) and quinolinic acid (QA) compared to wild-type mice
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• peritoneal macrophages show disrupted mitochondrial morphology and reduced numbers of mitochondria
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• primary mouse peritoneal macrophages exhibit reduced cellular NAD+ amounts and suppressed oxygen consumption while having increased glycolysis, thus disrupting macrophage respiration
• supplementation of peritoneal macrophages with kynurenine restores NAD+ levels and normalizes oxygen consumption and extracellular acidification rate
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• reduced ear swelling in a contact hypersensitivity assay with oxazolone
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• in a contact hypersensitivity assay with oxazolone
• however, lymph node cells treated with PMA and ionomycin exhibit normal secretion
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• in a contact hypersensitivity assay with oxazolone
• however, lymph node cells treated with PMA and ionomycin exhibit normal secretion
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• in a contact hypersensitivity assay with oxazolone
• however, lymph node cells treated with PMA and ionomycin exhibit normal secretion
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 10/29/2024 MGI 6.24 |
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